Impact of Interstitial Lung Disease on Mortality of Patients with Rheumatoid Arthritis
- Authors
- Kim, Dam; Cho, Soo-Kyung; Choi, Chan-Bum; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jung, Young Ok; Kim, Tae-Hwan; Kim, Tae-Jong; Lee, Hye-Soon; Lee, Joo Hyun; Lee, Jisoo; Lee, Shin-Seok; Yoo, Dae-Hyun; Yoon, Bo Young; Song, Jin Woo; Bae, Sang-Cheol; Sung, Yoon-Kyoung
- Issue Date
- Oct-2017
- Publisher
- Springer
- Keywords
- Interstitial lung disease; Rheumatoid arthritis; Prevalence; Mortality
- Citation
- ARTHRITIS & RHEUMATOLOGY, v.37, no.10, pp.1735 - 1745
- Indexed
- SCIE
SCOPUS
- Journal Title
- ARTHRITIS & RHEUMATOLOGY
- Volume
- 37
- Number
- 10
- Start Page
- 1735
- End Page
- 1745
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/136087
- DOI
- 10.1007/s00296-017-3781-7
- ISSN
- 1437-160X
- Abstract
- To identify the prevalence of interstitial lung disease (ILD) in Korean patients with rheumatoid arthritis (RA) and assess its effect on mortality. A total of 3555 patients with RA, with chest X-ray or chest computed tomography (CT) data at enrollment were extracted from the KORean Observational study Network for Arthritis cohort, a nationwide prospective cohort for patients with RA in Korea. The patients were classified into two groups: (1) an ILD group by chest X-ray or chest CT scan, and (2) a non-ILD group by these modalities. After comparing the characteristics of the groups at enrollment, mortalities were compared using the log-rank test. To explore the impact of ILD on mortality, Cox proportional hazard models were used. Sixty-four patients (1.8%) were identified with ILD. Male and older patients were more common in the ILD group. During a mean follow-up of 24 months, 6 patients (9.4%) in the ILD group and 25 patients (0.7%) in the non-ILD group died; the survival rate was significantly worse in the ILD group (p < 0.01). On adjusted analysis, ILD was significantly associated with increased mortality (HR 7.89, CI 3.16–19.69, p < 0.01); the risk of death in patients with ILD was even higher than in patients with cardiovascular disease (CVD, HR 4.10, CI 1.79–9.37, p < 0.01). The prevalence of ILD was 1.8% in Korean patients with RA. ILD is a major risk factor for mortality in patients with RA.
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