N-3 PUFA ameliorated bone loss induced by postmenopausal depression following exposure to chronic mild stress and maternal separation by regulating neuronal processes
DC Field | Value | Language |
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dc.contributor.author | Choi, Jeong-Eun | - |
dc.contributor.author | Hong, Yuni | - |
dc.contributor.author | Heo, Juhee | - |
dc.contributor.author | Park, | - |
dc.date.accessioned | 2022-07-06T02:13:52Z | - |
dc.date.available | 2022-07-06T02:13:52Z | - |
dc.date.created | 2022-01-06 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138430 | - |
dc.description.abstract | Depression induced by chronic mild stress (CMS) reduced bone mass in ovariectomized (OVX) rats, and maternal separation (MS) during early life aggravated depression-induced bone mass destruction. N-3 polyunsaturated fatty acids (PUFA) have been shown to improve bone mass and depression, but the bone-protecting effects of n-3 PUFA were unclear in CMS+MS-induced depression models. The purpose of this study was to determine whether n-3 PUFA improved CMS+MS-induced postmenopausal bone loss via its antidepressant-like action. Rats were fed diets containing 0% of total energy intake (en %) of n-3 PUFA during lifetime or 1 en % n-3 PUFA during pre-weaning or post-weaning periods, or their entire lifetimes and were allocated to CMS or CMS+MS groups after OVX. Lifetime supply of n-3 PUFA enhanced bone mass and microarchitecture, and expression of runt-related transcription factor 2, while decreasing blood levels of amino-terminal cross-linked telopeptide of type 1 collagen and the expression of receptor activator of nuclear factor kappa Β ligand/osteoprotegerin, activating transcription factor 4, and adrenergic receptor β2. Lifetime supply of n-3 PUFA decreased levels of adrenocorticotropic hormone and corticosterone and the expression of corticotropin-releasing factor in the brain but increased expression of the glucocorticoid receptor, serotonin-2C receptor, cAMP response element-binding protein (CREB), and calmodulin kinase IV and serotonin levels. Supply of n-3 PUFA during the pre-and post-weaning periods had beneficial effects on the brain but not on the bones. Lifetime supply of n-3 PUFA ameliorated bone loss induced by chronic stress by regulating hypothalamic-pituitary-adrenal axis activity and serotonin-CREB signaling. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.title | N-3 PUFA ameliorated bone loss induced by postmenopausal depression following exposure to chronic mild stress and maternal separation by regulating neuronal processes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, | - |
dc.identifier.doi | 10.1016/j.jnutbio.2021.108909 | - |
dc.identifier.scopusid | 2-s2.0-85120885760 | - |
dc.identifier.wosid | 000734322000007 | - |
dc.identifier.bibliographicCitation | Journal of Nutritional Biochemistry, v.100, pp.1 - 11 | - |
dc.relation.isPartOf | Journal of Nutritional Biochemistry | - |
dc.citation.title | Journal of Nutritional Biochemistry | - |
dc.citation.volume | 100 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | POLYUNSATURATED FATTY-ACIDS | - |
dc.subject.keywordPlus | DOCOSAHEXAENOIC ACID | - |
dc.subject.keywordPlus | 17-BETA-ESTRADIOL INJECTION | - |
dc.subject.keywordPlus | FISH-OIL | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | VULNERABILITY | - |
dc.subject.keywordPlus | PARAMETERS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordAuthor | Bone loss | - |
dc.subject.keywordAuthor | Chronic mild stress | - |
dc.subject.keywordAuthor | Maternal separation | - |
dc.subject.keywordAuthor | n-3 polyunsaturated fatty acid | - |
dc.subject.keywordAuthor | Ovariectomy | - |
dc.subject.keywordAuthor | Postmenopausal depression | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0955286321003296?via%3Dihub | - |
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