Development and Validity Assessment of a Self-evaluation Questionnaire for Functional Dyspepsia: A Multicenter Prospective Study in Koreaopen accessDevelopment and Validity Assessment of a Self-evaluation Questionnaire for Functional Dyspepsia: A Multicenter Prospective Study in Korea
- Other Titles
- Development and Validity Assessment of a Self-evaluation Questionnaire for Functional Dyspepsia: A Multicenter Prospective Study in Korea
- Authors
- Jung, Kyoungwon; Jung, Hye-Kyung; Kwon, Joong Goo; Tae, Chung Hyun; Bang, Ki Bae; Park, Jong Kyu; Lee, Ju Yup; Shin, Cheol Min; Oh, Jung Hwan; Song, Kyung Ho; Lee, Oh Young; Choi, Myung-Gyu
- Issue Date
- Jan-2022
- Publisher
- KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
- Keywords
- Dyspepsia; Patient outcome assessment; Surveys and questionnaires; Validation study
- Citation
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY, v.28, no.1, pp.111 - 120
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
- Volume
- 28
- Number
- 1
- Start Page
- 111
- End Page
- 120
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138441
- DOI
- 10.5056/jnm20250
- ISSN
- 2093-0879
- Abstract
- Background/Aims
Patient-reported outcomes (PROs) are essential for clinical decision making, conduction of clinical research, and drug application acquisition in functional gastrointestinal disorders. The aim of this study is to develop a PRO instrument and to determine the respondents’ perception of the efficacy of therapeutic agents for functional dyspepsia (FD).
Methods
A self-evaluation questionnaire for dyspepsia (SEQ-DYSPEPSIA) was developed and validated through a structured process. The 2-week reproducibility was evaluated, and the construct validity was assessed by correlating the scores of SEQ-DYSPEPSIA (including typical and major FD symptom subscales). Finally, the response to medication was assessed by comparing the changes after 4 weeks of treatment.
Results
A total of 193 Korean patients (age 48.5 ± 13.6 years, 69.4% women) completed the questionnaire. SEQ-DYSPEPSIA with 11 items had a good internal consistency (alpha = 0.770-0.905) and an acceptable test-retest reliability (intraclass correlation coefficient = 0.733-0.859). The self-evaluation questionnaire (SEQ)-major FD score highly correlated with the postprandial fullness/early satiety domain of the Patient Assessment of Gastrointestinal Symptom Severity Index (correlation coefficient r = 0.741, P < 0.001), Nepean Dyspepsia Index-Korean version (NDI-K) (r = 0.839, P < 0.001), and NDI-K quality of life (r = −0.275 to −0.344, P < 0.001). After medical treatment, decrease in the SEQ-typical FD and SEQ-major FD was significantly greater in the responder group than in nonresponder group (P = 0.019 and P = 0.009, respectively).
Conclusion
This study suggests that the Korean version of SEQ-DYSPEPSIA has good reliability and validity, and can be a useful PRO measurement tool in patients with FD.
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