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Biodegradable silicon nanoneedles for ocular drug delivery

Authors
Park, WoohyunVan Phuc NguyenJeon, YaleKim, BongjoongLi, YanxiuYi, JonghunKim, HyungjunLeem, Jung WooKim, Young L.Kim, Dong RipPaulus, Yannis M.Lee, Chi Hwan
Issue Date
Apr-2022
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Citation
SCIENCE ADVANCES, v.8, no.13, pp.1 - 12
Indexed
SCIE
SCOPUS
Journal Title
SCIENCE ADVANCES
Volume
8
Number
13
Start Page
1
End Page
12
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138913
DOI
10.1126/sciadv.abn1772
ISSN
2375-2548
Abstract
Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases.
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