Prolonged Endurance Exercise Adaptations Counteract Doxorubicin Chemotherapy-Induced Myotoxicity in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Insu | - |
dc.contributor.author | Go, Gwang-Woong | - |
dc.contributor.author | Lee, Youngil | - |
dc.contributor.author | Kim, Jong-Hee | - |
dc.date.accessioned | 2022-07-06T06:22:47Z | - |
dc.date.available | 2022-07-06T06:22:47Z | - |
dc.date.created | 2022-05-04 | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2076-3417 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/138938 | - |
dc.description.abstract | Doxorubicin (DOX) is a potent chemotherapeutic agent widely used for various types of cancer; however, its accumulation causes myotoxicity and muscle atrophy. Endurance exercise (EXE) has emerged as a vaccine against DOX-induced myotoxicity. However, potential molecular mechanisms of EXE-mediated myocyte protection for the unfavorable muscle phenotype remain unelucidated. In addition, most studies have identified the short-term effects of DOX and EXE interventions, but studies on the prolonged EXE effects used as adjuvant therapy for chronic DOX treatment are lacking. Twelve-week-old adult male C57BL/6J mice were assigned to four groups: sedentary treated with saline (SED-SAL, n = 10), endurance exercise treated saline (EXE-SAL, n = 10), sedentary treated with doxorubicin (SED-DOX, n = 10), and endurance exercise treated with doxorubicin (EXE-DOX, n = 10). Mice were intraperitoneally injected with DOX (5 mg/kg) or saline five times biweekly for eight weeks, while a treadmill running exercise was performed. Body composition was assessed and then soleus muscle tissues were excised for histological and biochemical assays. Our data showed that DOX aggravated body composition, absolute soleus muscle mass, and distinct pathological features; also, TOP2B upregulation was linked to DOX-induced myotoxicity. We also demonstrated that EXE-DOX promoted mitochondrial biogenesis (e.g., citrate synthase). However, no alterations in satellite cell activation and myogenesis factors in response to DOX and EXE interventions were observed. Instead, SED-DOX promoted catabolic signaling cascades (AKT-FOXO3 alpha-MuRF-1 axis), whereas EXE-DOX reversed its catabolic phenomenon. Moreover, EXE-DOX stimulated basal autophagy. We showed that the EXE-mediated catabolic paradigm shift is likely to rescue impaired muscle integrity. Thus, our study suggests that EXE can be recommended as an adjuvant therapy to ameliorate DOX-induced myotoxicity. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Prolonged Endurance Exercise Adaptations Counteract Doxorubicin Chemotherapy-Induced Myotoxicity in Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Gwang-Woong | - |
dc.contributor.affiliatedAuthor | Kim, Jong-Hee | - |
dc.identifier.doi | 10.3390/app12073652 | - |
dc.identifier.scopusid | 2-s2.0-85128614683 | - |
dc.identifier.wosid | 000781788200001 | - |
dc.identifier.bibliographicCitation | APPLIED SCIENCES-BASEL, v.12, no.7, pp.1 - 18 | - |
dc.relation.isPartOf | APPLIED SCIENCES-BASEL | - |
dc.citation.title | APPLIED SCIENCES-BASEL | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | CANCER CACHEXIA | - |
dc.subject.keywordPlus | LOADING CONTROL | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | ATROPHY | - |
dc.subject.keywordPlus | ACTIN | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | myotoxicity | - |
dc.subject.keywordAuthor | endurance exercise | - |
dc.subject.keywordAuthor | skeletal muscle | - |
dc.subject.keywordAuthor | proteolytic system | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | body composition | - |
dc.subject.keywordAuthor | topoisomerase II beta | - |
dc.subject.keywordAuthor | AKT-FOXO3 alpha-MuRF-1 | - |
dc.identifier.url | https://www.mdpi.com/2076-3417/12/7/3652 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.