Efficacy of Human Adipose-Derived Stem Cells in Spinal Fusion in a Rat Ovariectomy Osteoporosis Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, Min Kyun | - |
dc.contributor.author | Bae, In-Suk | - |
dc.contributor.author | Yi, Hyeong-Joong | - |
dc.contributor.author | Do, Byung-Rok | - |
dc.contributor.author | Kim, Kee D. | - |
dc.contributor.author | Chun, Hyoung-Joon | - |
dc.date.accessioned | 2022-07-06T08:37:28Z | - |
dc.date.available | 2022-07-06T08:37:28Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 1019-5149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139291 | - |
dc.description.abstract | AIM: To evaluate the efficacy of human adipose-derived stem cells (h-ADSCs) in spinal fusion in an osteoporotic rat model. MATERIAL and METHODS: Female Sprague-Dawley rats (n=40) underwent ovariectomy and were then randomly assigned into two groups: ovariectomy (OVX) (OVX + fusion) and h-ADSCs (OVX + fusion + h-ADSCs). Six weeks after OVX, we performed bilateral lumbar spinal fusion using the autologous iliac bone with or without administration of h-ADSCs. The efficacy of the spinal fusion was then assessed using manual palpation, lateral ending, morphogenic examinations, and histology six weeks the after fusion procedure. RESULTS: Fusion bed volume was different between the two groups but not significantly. However, the fusion bed density was higher in the h-ADSC group than in the OVX group. Manual palpation (70% vs. 40%, p=0.112) and lateral bending (95% vs. 55%, p=0.011) produced higher fusion rates in the h-ADSC group than in the OVX group. Additionally, a histologic examination revealed new bone formation at the fusion bed between the lamina and implanted iliac crest bone in the h-ADSC group, whereas, in the OVX group, the fusion masses were composed of fibroblastic proliferation. CONCLUSION: Our study demonstrates that the administration of h-ADSCs may have advantages in bone formation and consolidation but does not lead to bone overgrowth. These findings indicate that the administration of h-ADSCs is an alternative and efficient method for spinal fusion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TURKISH NEUROSURGICAL SOC | - |
dc.title | Efficacy of Human Adipose-Derived Stem Cells in Spinal Fusion in a Rat Ovariectomy Osteoporosis Model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Min Kyun | - |
dc.contributor.affiliatedAuthor | Yi, Hyeong-Joong | - |
dc.contributor.affiliatedAuthor | Chun, Hyoung-Joon | - |
dc.identifier.doi | 10.5137/1019-5149.JTN.33739-21.4 | - |
dc.identifier.scopusid | 2-s2.0-85126961977 | - |
dc.identifier.wosid | 000771800500010 | - |
dc.identifier.bibliographicCitation | TURKISH NEUROSURGERY, v.32, no.2, pp.251 - 260 | - |
dc.relation.isPartOf | TURKISH NEUROSURGERY | - |
dc.citation.title | TURKISH NEUROSURGERY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | 260 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | MULTILINEAGE CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | OSTEOGENESIS | - |
dc.subject.keywordAuthor | Adipose-derived stem cell | - |
dc.subject.keywordAuthor | Spinal fusion | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Ovariectomy | - |
dc.identifier.url | http://www.turkishneurosurgery.org.tr/abstract.php?id=2605 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
222, Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea+82-2-2220-1365
COPYRIGHT © 2021 HANYANG UNIVERSITY.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.