Emerging role of bystander T cell activation in autoimmune diseases
DC Field | Value | Language |
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dc.contributor.author | Shim, Chae-Hyeon | - |
dc.contributor.author | Cho, Sookyung | - |
dc.contributor.author | Shin, Young-Mi | - |
dc.contributor.author | Choi, Je-Min | - |
dc.date.accessioned | 2022-07-06T10:14:46Z | - |
dc.date.available | 2022-07-06T10:14:46Z | - |
dc.date.created | 2022-04-06 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139497 | - |
dc.description.abstract | Autoimmune disease is known to be caused by unregulated selfantigen-specific T cells, causing tissue damage. Although antigen specificity is an important mechanism of the adaptive immune system, antigen non-related T cells have been found in the inflamed tissues in various conditions. Bystander T cell activation refers to the activation of T cells without antigen recognition. During an immune response to a pathogen, bystander activation of self-reactive T cells via inflammatory mediators such as cytokines can trigger autoimmune diseases. Other antigen-specific T cells can also be bystander-activated to induce innate immune response resulting in autoimmune disease pathogenesis along with self-antigen-specific T cells. In this review, we summarize previous studies investigating bystander activation of various T cell types (NKT, gamma delta T cells, MAIT cells, conventional CD4+, and CD8+ T cells) and discuss the role of innate-like T cell response in autoimmune diseases. In addition, we also review previous findings of bystander T cell function in infection and cancer. A better understanding of bystander-activated T cells versus antigenstimulated T cells provides a novel insight to control autoimmune disease pathogenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Emerging role of bystander T cell activation in autoimmune diseases | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Je-Min | - |
dc.identifier.doi | 10.5483/BMBRep.2022.55.2.183 | - |
dc.identifier.scopusid | 2-s2.0-85125290815 | - |
dc.identifier.wosid | 000763606900001 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.55, no.2, pp.57 - 64 | - |
dc.relation.isPartOf | BMB REPORTS | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 55 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 64 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002813067 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MEMORY CD4(+) | - |
dc.subject.keywordPlus | INNATE-LIKE | - |
dc.subject.keywordPlus | IFN-GAMMA | - |
dc.subject.keywordPlus | NKT CELLS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | IL-1 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | Antigen specificity | - |
dc.subject.keywordAuthor | Autoimmune disease | - |
dc.subject.keywordAuthor | Bystander T cell activation | - |
dc.subject.keywordAuthor | Innate-like functions | - |
dc.identifier.url | https://www.bmbreports.org/journal/view.html?doi=10.5483/BMBRep.2022.55.2.183 | - |
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