베타카로틴 함유 키토산/하이알루론산 나노캡슐의 용해도 및 재분산성 특성Properties of β-carotene-loaded chitosan/hyaluronic acid nanocapsules: solubility and redispersibility
- Other Titles
- Properties of β-carotene-loaded chitosan/hyaluronic acid nanocapsules: solubility and redispersibility
- Authors
- 안은정; 이지수; 이현규
- Issue Date
- Feb-2022
- Publisher
- 한국식품과학회
- Keywords
- β-carotene; solubility; nanoencapsulation; hyaluronic acid; redispersibility
- Citation
- 한국식품과학회지, v.54, no.1, pp.66 - 74
- Indexed
- SCOPUS
KCI
- Journal Title
- 한국식품과학회지
- Volume
- 54
- Number
- 1
- Start Page
- 66
- End Page
- 74
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139558
- DOI
- 10.9721/KJFST.2022.54.1.66
- ISSN
- 0367-6293
- Abstract
- To improve the solubility of β-carotene, three types of β-carotene-loaded nanocapsules were prepared using chitosan (CS) and two cross-linkers, sodium tripolyphosphate (TPP) and hyaluronic acid (HA), alone or in combination (CS-TPP, CS-TPP-HA, and CS-HA). The entrapment efficiency of all nanocapsules significantly increased with an increase in TPP and HA, with the efficiency ranging from 95% to 99%. The solubility of β-carotene was significantly improved by CS nanoencapsulation before and after lyophilization and during storage. CS/HA nanoencapsulation significantly improved (by 11-fold) the water solubility of β-carotene. In particular, CS/HA nanoencapsulation was the most effective in terms of not only the solubility of β-carotene, but also the redispersibility ratio. Therefore, CS/HA encapsulation could be useful for improving the solubility of poorly soluble active ingredients, such as β-carotene.
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