Potential threats of nanoplastic accumulation in human induced pluripotent stem cells
- Authors
- Jeong, Hyejoong; Kim, Wijin; Choi, Daheui; Heo, Jiwoong; Han, Uiyoung; Jung, Se Yong; Park, Hee Ho; Hong, Sung-Tae; Park, Ju Hyun; Hong,Jinkee
- Issue Date
- Jan-2022
- Publisher
- Elsevier B.V.
- Keywords
- Bioaccumulation; Developmental toxicology; Induced Pluripotent Stem Cell; Long-term toxicity; Microplastic; Nanoplastic
- Citation
- Chemical Engineering Journal, v.427, pp.1 - 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical Engineering Journal
- Volume
- 427
- Start Page
- 1
- End Page
- 9
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139711
- DOI
- 10.1016/j.cej.2021.131841
- ISSN
- 1385-8947
- Abstract
- The threat to humans from nanoplastics (NPs) is increasing invisibly. Nowadays, many people are concerned about human safety and health, but few are reported about the effects of NP on humans. To overcome the limitations in human studies, human induced pluripotent stem cells (hiPSCs) were used as an optimal platform to investigate toxicity and subtle changes in differentiation caused by intracellular NPs accumulation for a long-term. Negatively charged polystyrene nanoplastics (PS NPs) were used to exclude acute toxic issues of surface charge and investigate the impact of the NP's size and nature during bioaccumulation. Intracellular observations revealed that excessive amounts of NPs were internalized into single cells and colonies within 48 h. Substantial growth inhibition and a slight reduction in self renewal capacity of hiPSCs occurred with respect to internalized NPs. Unexpectedly, the accumulated NPs in hiPSC did not exhibit chronic toxicity or adversely affect differentiation for 14 days.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/139711)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.