Polypeptide-Based K+Ionophore as a Strong Immunogenic Cell Death Inducer for Cancer Immunotherapy
- Authors
- Lee, DaeYong; Ha, JongHoon; Ahn, Hyomin; Jeong, Seong Dong; Jeong, MoonKyoung; Park, Ji-Ho; Yun, Chae-Ok; Kim, Yeu-Chun
- Issue Date
- Dec-2021
- Publisher
- American Chemical Society
- Keywords
- DAMP release; dendritic cell maturation; ER stress; immunogenic cell death; potassium ion efflux
- Citation
- ACS Applied Bio Materials, v.4, no.12, pp.8333 - 8342
- Indexed
- SCOPUS
- Journal Title
- ACS Applied Bio Materials
- Volume
- 4
- Number
- 12
- Start Page
- 8333
- End Page
- 8342
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140161
- DOI
- 10.1021/acsabm.1c00861
- ISSN
- 2576-6422
- Abstract
- Immunogenic cell death (ICD) is a key factor for generating antitumor immunity. Endoplasmic reticulum (ER) stress triggers the release of damage-associated molecular patterns (DAMPs), thus inducing immunogenicity. We developed a polypeptide-based K+ ionophore that perturbed ion homeostasis and elicited a prolonged ER stress. The ER stress not only fosters an oxidative environment that activates mitochondria-dependent apoptosis pathways but also drives immune responses by releasing DAMPs. The ionophore suppressed tumor proliferation in vitro and in vivo based on the pro-apoptotic activity and immunogenicity.
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