Effect of discontinuation of an antimicrobial stewardship programme on the antibiotic usage patternopen access
- Authors
- Jang, Wooyoung; Hwang,Hyeonjun; Jo, Hyun-uk; Cha, Yong-Han; Kim, Bongyoung
- Issue Date
- Dec-2021
- Publisher
- Elsevier B.V.
- Keywords
- Antibiotic use; Antimicrobial resistance; Antimicrobial stewardship; Hospital; Korea
- Citation
- Clinical Microbiology and Infection, v.27, no.12, pp.1860.e1 - 1860.e5
- Indexed
- SCIE
SCOPUS
- Journal Title
- Clinical Microbiology and Infection
- Volume
- 27
- Number
- 12
- Start Page
- 1860.e1
- End Page
- 1860.e5
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140236
- DOI
- 10.1016/j.cmi.2021.07.019
- ISSN
- 1198-743X
- Abstract
- Objectives: This study aimed to analyse the effect of discontinuation of antimicrobial stewardship programme (ASP) activity on the usage pattern of antibiotics. Methods: An interrupted time-series analysis assessing the trends in antibiotic use was conducted between September 2015 and August 2019 in an 859-bed university-affiliated hospital in Korea, where all ASP activities were discontinued in March 2018. The major activity of the ASP was a restrictive antibiotic programme. Results: The use of restrictive antibiotics increased immediately after the discontinuation of the ASP by 41.06 days of therapy (DOT)/1000 patient-days in the general ward (95% confidence interval (CI) 21.04–61.08) and by 391.04 DOT/1000 patient-days in the intensive care unit (ICU) (95%CI 207.56–574.51). In addition, there were positive changes in the slope for the use of restrictive antibiotics in the general ward (7.06 DOT/1000 patient-days per month, 95%CI 4.63–9.50) and ICU (35.95 DOT/1000 patient-days per month, 95%CI 18.70–53.19). The use of broad-spectrum antibiotics in the general ward significantly decreased (–87.54 DOT/1000 patient-days, 95%CI –149.29 to –25.79). For non-broad-spectrum antibiotics, there were positive changes in the slope in the general ward (16.54 DOT/1000 patient-days per month, 95%CI 12.99–20.09) and ICU (12.85 DOT/1000 patient-days per month, 95%CI 2.32–23.38). Conclusions: After discontinuation of the ASP, antibiotic usage patterns rapidly returned to the patterns prior to the implementation of the programme. © 2021 European Society of Clinical Microbiology and Infectious Diseases
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.