Predicting Factors of Severe COVID-19 in Patients With Asthma: A Korean National Cohort Studyopen access
- Authors
- Lee, Hyun; Cho, Hayoung; Lee, Sun-Kyung; Park, Tai Sun; Park, Dong Won; Moon, Ji-Yong; Kim, Tae-Hyung; Sohn, Jang Won; Yoon, Ho Joo; Kim, Sang-Heon
- Issue Date
- Nov-2021
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Asthma; COVID-19; chronic obstructive pulmonary disease
- Citation
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, v.13, no.6, pp.939 - 944
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
- Volume
- 13
- Number
- 6
- Start Page
- 939
- End Page
- 944
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140587
- DOI
- 10.4168/aair.2021.13.6.939
- ISSN
- 2092-7355
- Abstract
- As there are limited data on the disease course of and factors predicting severe coronavirus disease 19 (COVID-19) in patients with asthma, this study aims to perform a detailed analysis of the clinical course of asthmatic patients with COVID-19 and evaluate factors related to severe infection. Of the 5,628 patients confirmed with COVID-19, 128 (2.3%) had asthma. Among the 128 asthmatic patients, 32 (25%) had severe COVID-19 and 96 (75%) had non-severe COVID-19. Among asthmatic patients, those with severe COVID-19 were significantly older and had more dyspnea and fever, more comorbidities, and lower lymphocyte and platelet counts than those with non-severe COVID-19. In multivariable logistic regression analysis, chronic obstructive pulmonary disease (adjusted odds ratio [aOR], 6.49; 95% confidence interval [CI], 1.18–41.81), low lymphocyte proportion (aOR, 0.91; 95% CI, 0.86–0.97), and low platelet count (aOR, 0.99; 95% CI, 0.98–0.99) were independently associated with severe COVID-19.
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