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Loss of DUSP4 Expression as a Prognostic Biomarker in Clear Cell Renal Cell Carcinomaopen access

Authors
Bang, SeongsikJee, SeungyunSon, HwangkyuWi, Young ChanKim, HyunsungPark, HosubMyung, JaekyungShin, Su-JinPaik, Seung Sam
Issue Date
Oct-2021
Publisher
MDPI
Keywords
renal cell carcinoma; DUSP4; dual-specificity protein phosphatase 4; prognosis
Citation
DIAGNOSTICS, v.11, no.10, pp.1 - 10
Indexed
SCIE
SCOPUS
Journal Title
DIAGNOSTICS
Volume
11
Number
10
Start Page
1
End Page
10
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140793
DOI
10.3390/diagnostics11101939
ISSN
2075-4418
Abstract
Dual-specificity protein phosphatase 4 (DUSP4) is a negative regulator of mitogen-activated protein kinases. The prognostic impact of DUSP4 expression in renal cell carcinoma is not well studied. Therefore, we evaluated the clinicopathological implications of DUSP4 expression in clear cell renal cell carcinoma by performing immunohistochemistry (IHC). The clinical outcome according to DUSP4 expression was evaluated through survival analyses, and the association between mRNA expression and prognosis was confirmed by online analysis (Kaplan-Meier plotter). Loss of DUSP4 expression was noted in most histological subtypes of renal cell carcinoma. Loss of DUSP4 expression in clear cell renal cell carcinoma was significantly correlated with old age (p = 0.033), high histologic grade (p < 0.001), tumor necrosis (p < 0.001), and high pT category (p < 0.001). In survival analysis, loss of DUSP4 expression was associated with poor clinical outcomes in cancer-specific survival and recurrence-free survival (p = 0.010 and p = 0.007, respectively). Upon TCGA data analysis, patients with low DUSP4 mRNA expression showed a shorter overall survival (p = 0.023). These results suggest that loss of DUSP4 expression can be used as a potential biomarker for predicting clinical outcomes in clear cell renal cell carcinoma patients.
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