Genetic Relatedness of 5-Year Isolates of Clostridioides difficile Polymerase Chain Reaction Ribotype 017 Strains in a Hospital
DC Field | Value | Language |
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dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Seo, Mi-Ran | - |
dc.contributor.author | Kim, Bongyoung | - |
dc.contributor.author | Kim, Jinyeong | - |
dc.contributor.author | Bae, Mi-Hyun | - |
dc.contributor.author | Pai, Hyunjoo | - |
dc.date.accessioned | 2022-07-06T12:05:02Z | - |
dc.date.available | 2022-07-06T12:05:02Z | - |
dc.date.created | 2021-12-08 | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140833 | - |
dc.description.abstract | The objective of this study was to analyse the genetic relatedness of Clostridioides difficile polymerase chain reaction ribotype 017 (RT017) strains from patients with hospital-acquired C. difficile infection (HA-CDI) in a hospital with a high RT017 prevalence. From 2009 to 2013, 200 RT017 strains (26.8%) were collected from 745 HA-CDI patient isolates. They comprised 64 MLVA types, and 197 (98.5%) strains were genetically related to 5 clonal complexes (CCs). The largest cluster, CC-A, included 163 isolates of 40 MLVA types. CC-A accounted for 20% of RT017 strains in 2009 and sharply increased to 94.9% in 2010, 94% in 2011, 86.2% in 2012, and 73.5% in 2013. The other 4 CCs included 20 isolates with 7 MLVA types. The resistance rates of antimicrobials were as follows: clindamycin 100%, moxifloxacin 99%, rifaximin 88.5%, and vancomycin 1%. All isolates were susceptible to metronidazole and piperacillin/tazobactam. Comparing antibiotic resistance among CCs, the geometric mean of the minimum inhibitory concentrations of moxifloxacin, vancomycin, and piperacillin/tazobactam were significantly higher for CC-A isolates than for the other CCs. RT017 clones constantly evolved over the 5 years studied with regard to genetic relatedness. The levels of antibiotic resistance may contribute to the persistence of organisms in the institution. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Genetic Relatedness of 5-Year Isolates of Clostridioides difficile Polymerase Chain Reaction Ribotype 017 Strains in a Hospital | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jieun | - |
dc.contributor.affiliatedAuthor | Kim, Bongyoung | - |
dc.contributor.affiliatedAuthor | Bae, Mi-Hyun | - |
dc.contributor.affiliatedAuthor | Pai, Hyunjoo | - |
dc.identifier.doi | 10.3390/antibiotics10101229 | - |
dc.identifier.scopusid | 2-s2.0-85117416045 | - |
dc.identifier.wosid | 000719396300001 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, v.10, no.10, pp.1 - 10 | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.citation.title | ANTIBIOTICS-BASEL | - |
dc.citation.volume | 10 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MULTILOCUS VARIABLE-NUMBER | - |
dc.subject.keywordPlus | TANDEM-REPEAT ANALYSIS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | OUTBREAK | - |
dc.subject.keywordAuthor | Clostridioides difficile | - |
dc.subject.keywordAuthor | ribotype 017 | - |
dc.subject.keywordAuthor | genetic relatedness | - |
dc.subject.keywordAuthor | MLVA | - |
dc.subject.keywordAuthor | antibiotic resistance | - |
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