Genetic Relatedness of 5-Year Isolates of Clostridioides difficile Polymerase Chain Reaction Ribotype 017 Strains in a Hospitalopen access
- Authors
- Kim, Jieun; Seo, Mi-Ran; Kim, Bongyoung; Kim, Jinyeong; Bae, Mi-Hyun; Pai, Hyunjoo
- Issue Date
- Oct-2021
- Publisher
- MDPI
- Keywords
- Clostridioides difficile; ribotype 017; genetic relatedness; MLVA; antibiotic resistance
- Citation
- ANTIBIOTICS-BASEL, v.10, no.10, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIBIOTICS-BASEL
- Volume
- 10
- Number
- 10
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/140833
- DOI
- 10.3390/antibiotics10101229
- ISSN
- 2079-6382
- Abstract
- The objective of this study was to analyse the genetic relatedness of Clostridioides difficile polymerase chain reaction ribotype 017 (RT017) strains from patients with hospital-acquired C. difficile infection (HA-CDI) in a hospital with a high RT017 prevalence. From 2009 to 2013, 200 RT017 strains (26.8%) were collected from 745 HA-CDI patient isolates. They comprised 64 MLVA types, and 197 (98.5%) strains were genetically related to 5 clonal complexes (CCs). The largest cluster, CC-A, included 163 isolates of 40 MLVA types. CC-A accounted for 20% of RT017 strains in 2009 and sharply increased to 94.9% in 2010, 94% in 2011, 86.2% in 2012, and 73.5% in 2013. The other 4 CCs included 20 isolates with 7 MLVA types. The resistance rates of antimicrobials were as follows: clindamycin 100%, moxifloxacin 99%, rifaximin 88.5%, and vancomycin 1%. All isolates were susceptible to metronidazole and piperacillin/tazobactam. Comparing antibiotic resistance among CCs, the geometric mean of the minimum inhibitory concentrations of moxifloxacin, vancomycin, and piperacillin/tazobactam were significantly higher for CC-A isolates than for the other CCs. RT017 clones constantly evolved over the 5 years studied with regard to genetic relatedness. The levels of antibiotic resistance may contribute to the persistence of organisms in the institution.
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