Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification
- Authors
- Yun, Jinyoung; Jeong, Yeonsu; Nam, Onyou; Yeo, Ki Baek; Jo, Yun Kee; Heo, Hye Ryoung; Kim, Chang Sup; Il Joo, Kye; Pack, Seung Pil; Jin, EonSeon; Cha, Hyung Joon
- Issue Date
- Aug-2021
- Publisher
- AMER CHEMICAL SOC
- Keywords
- coccoliths; biosilica; biomineral; bone substitutes; bone regeneration
- Citation
- ACS APPLIED BIO MATERIALS, v.4, no.8, pp.6046 - 6055
- Indexed
- SCOPUS
- Journal Title
- ACS APPLIED BIO MATERIALS
- Volume
- 4
- Number
- 8
- Start Page
- 6046
- End Page
- 6055
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141333
- DOI
- 10.1021/acsabm.1c00346
- ISSN
- 2576-6422
- Abstract
- Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophorederived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141333)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.