Conjugation of prostate cancer-specific aptamers to polyethylene glycol-grafted polyethylenimine for enhanced gene delivery to prostate cancer cells
- Authors
- Lee, Jaewon; Oh, Jungju; Lee, Eun-song; Kim, Young-Pil; Lee, Minhyung
- Issue Date
- May-2019
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Aptamer; Prostate cancer; Gene delivery; Polyethylene glycol; Polyethylenimine
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.73, pp.182 - 191
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 73
- Start Page
- 182
- End Page
- 191
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/14178
- DOI
- 10.1016/j.jiec.2019.01.023
- ISSN
- 1226-086X
- Abstract
- Prostate cancer is one of the most frequently diagnosed cancers. In this study, a prostate cancer-specific aptamer, Wy5a, was conjugated to polyethylenimine (PEI) with a polyethylene glycol (PEG) linker for prostate cancer-specific gene delivery. PEI-PEG-AS1411 was synthesized as a non-specific control. PEI-PEG-Wy5a formed complexes with plasmid DNA in a spherical form with a diameter of 70 nm and a positive surface-charge. In transfection assays, PEI-PEG-Wy5a had higher gene delivery efficiency to PC-3 prostate cancer cells than did PEI-PEG or PEI-PEG-AS1411, but not in other types of cells. The results suggest that PEI-PEG-Wy5a may be useful for prostate cancer-specific gene delivery. (C) 2019 The Korean Society of Industrial and Engineering Chemistry.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
- 서울 자연과학대학 > 서울 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/14178)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.