A novel genotype of hantaan orthohantavirus harbored by apodemus agrarius chejuensis as a potential etiologic agent of hemorrhagic fever with renal syndrome in Republic of Koreaopen access
- Authors
- Park, Kyungmin; Kim, Won-Keun; Lee, Seung-Ho; Kim, Jongwoo; Lee, Jingyeong; Cho, Seungchan; Lee, Geum-Young; Noid, Jin Sun; Lee, Keun Hwa; Song, Jin-Won
- Issue Date
- May-2021
- Publisher
- Public Library of Science
- Citation
- PLoS Neglected Tropical Diseases, v.15, no.5, pp.1 - 18
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLoS Neglected Tropical Diseases
- Volume
- 15
- Number
- 5
- Start Page
- 1
- End Page
- 18
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141922
- DOI
- 10.1371/journal.pntd.0009400
- ISSN
- 1935-2727
- Abstract
- Background Orthohantaviruses, causing hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome, pose a significant public health threat worldwide. Despite the significant mortality and morbidity, effective antiviral therapeutics for orthohantavirus infections are currently unavailable. This study aimed to investigate the prevalence of HFRS-associated orthohantaviruses and identify the etiological agent of orthohantavirus outbreaks in southern Republic of Korea (ROK). Methodology/Principal findings We collected small mammals on Jeju Island during 2018–2020. We detected the Hantaan virus (HTNV)-specific antibodies and RNA using an indirect immunofluorescence assay test and reverse transcription-polymerase chain reaction on Apodemus agrarius chejuensis (A. chejuensis). The prevalence of anti-HTNV antibodies among rodents was 14.1%. A total of six seropositive mouse harbored HTNV RNA. The amplicon-based next-generation sequencing provided nearly full-length tripartite genomic sequences of six HTNV harbored by A. chejuensis. Phylogenetic and tanglegram analyses were conducted for inferring evolutionary relationships between orthohantaviruses with their reservoir hosts. Phylogenetic analysis showed a novel distinct HTNV genotype. The detected HTNV genomic sequences were phylogenetically related to a viral sequence derived from HFRS patient in southern ROK. Tanglegram analysis demonstrated the segregation of HTNV genotypes correspond-ing to Apodemus spp. divergence. Conclusions/Significance Our results suggest that A. chejuensis-borne HTNV may be a potential etiological agent of HFRS in southern ROK. Ancestral HTNV may infect A. chejuensis prior to geological isolation between the Korean peninsula and Jeju Island, supporting the co-evolution of orthohan-taviruses and rodents. This study arises awareness among physicians for HFRS outbreaks in southern ROK.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 미생물학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141922)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.