The Role of Nkx3.1 in Cancers and Stemnessopen access
- Authors
- Antao, Ainsley Mike; Ramakrishna, Suresh; Kim, Kye-Seong
- Issue Date
- May-2021
- Publisher
- KOREAN SOC STEM CELL RESEARCH
- Keywords
- Cellular reprogramming; CARNs; Prostate development; Prostate cancer
- Citation
- INTERNATIONAL JOURNAL OF STEM CELLS, v.14, no.2, pp.168 - 179
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF STEM CELLS
- Volume
- 14
- Number
- 2
- Start Page
- 168
- End Page
- 179
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141980
- DOI
- 10.15283/ijsc20121
- ISSN
- 2005-3606
- Abstract
- The well-known androgen-regulated homeobox gene, NKX3.1, is located on the short arm of chromosome 8. It is the first known prostate epithelium-specific marker, and is a transcription factor involved in development of the testes and prostate. In addition to specifying the prostate epithelium and maintaining normal prostate secretory function, Nkx3.1 is an established marker for prostate cancer. Over the years, however, this gene has been implicated in various other cancers, and technological advances have allowed determination of its role in other cellular functions. Nkx3.1 has also been recently identified as a factor capable of replacing Oct4 in cellular reprogramming. This review highlights the role of this tumor suppressor and briefly describes its functions, ranging from prostate development to maintenance of stemness and cellular reprogramming.
- Files in This Item
-
- Appears in
Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/141980)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.