Deep optic nerve head morphology and glaucoma progression in eyes with and without laminar dot sign: a longitudinal comparative study
- Authors
- Bak, Eunoo; Lee, Won June; Kim, Jin-Soo; Lee, Jinho; Ha, Ahnul; Kim, Yong Woo; Girard, Michael J. A.; Mari, Jean Martial; Jeoung, Jin Wook; Kim, Young Kook; Park, Ki Ho
- Issue Date
- Mar-2021
- Publisher
- SPRINGERNATURE
- Citation
- EYE, v.35, no.3, pp.936 - 944
- Indexed
- SCIE
SCOPUS
- Journal Title
- EYE
- Volume
- 35
- Number
- 3
- Start Page
- 936
- End Page
- 944
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142270
- DOI
- 10.1038/s41433-020-1001-2
- ISSN
- 0950-222X
- Abstract
- Purpose
To investigate the association between the laminar dot sign (LDS) and the deep optic nerve head (ONH) structure in eyes with primary-open-angle glaucoma (POAG).
Methods
Eighty-four eyes of 84 patients with POAG were prospectively included. All of the patients underwent stereo optic disc photography (SDP), red-free retinal nerve fibre layer (RNFL) photography, SS-OCT, and standard automated perimetry. By evaluating the SDP, patients were classified into laminar dot sign (LDS) and non-LDS groups. The deep structure of the ONH including the anterior prelaminar depth (APLD) and prelaminar tissue thickness (PTT) were quantitated using SS-OCT. Progression was assessed by structural or functional deterioration during the average 4.3 ± 1.2 years of follow-up.
Results
The LDS group had deeper APLD (405.47 ± 107.55 vs. 302.45 ± 149.51, P < 0.001) and thinner PTT (74.34 ± 24.46 vs. 137.29 ± 40.07, P = 0.001) relative to the non-LDS group. By multivariate analysis, thin PTT was significantly associated with the presence of LDS (odds ratio = 0.939, P < 0.001). Structural progression was detected in 45 eyes (84.9%) in the LDS group and 8 eyes (25.8%) in the non-LDS group. Functional progression was demonstrated in 29 eyes (34.5%) in the LDS group and 6 eyes (19.4%) in the non-LDS group. The eyes with LDS had a significantly higher risk of glaucoma progression (χ2 = 5.00, degree of freedom = 1, P = 0.033).
Conclusions
In eyes with POAG, the presence of LDS was associated with thinner prelaminar tissue and faster disease progression.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의과대학 > 서울 안과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142270)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.