Association between Dyslipidemia and Chronic Rhinosinusitis in a Korean Populationopen access
- Authors
- Wee, Jee Hye; Min, Chanyang; Park, Min Woo; Byun, Soo Hwan; Lee, Hyo-Jeong; Song, Chang Myeon; Park, Bumjung; Choi, Hyo Geun
- Issue Date
- Jan-2021
- Publisher
- MDPI
- Keywords
- sinusitis; dyslipidemias; nasal polyps; inflammation; population surveillance
- Citation
- DIAGNOSTICS, v.11, no.1, pp.1 - 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- DIAGNOSTICS
- Volume
- 11
- Number
- 1
- Start Page
- 1
- End Page
- 10
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142486
- DOI
- 10.3390/diagnostics11010026
- ISSN
- 2075-4418
- Abstract
- This study aims to assess the relationship between chronic rhinosinusitis (CRS) and dyslipidemia in a Korean population. The population aged 40 years or over was selected from the Korean National Health Insurance Service-National Health Screening Cohort. CRS was defined if patients were treated ≥2 times with ICD-10 code (J32) and underwent head and neck computed tomography. Patients with CRS were classified as having nasal polyps (J33) or not. Dyslipidemia was defined if participants with the ICD-10 code (E78) were treated ≥2 times from 2002 to 2015. A total of 6163 patients with CRS were matched with 24,652 controls (1:4 ratio) for sex, age, income, and residence. The adjusted odds ratios (aORs) of a previous dyslipidemia in patients with CRS were analyzed by conditional logistic regression analysis, adjusted for confounding factors. The prevalence of dyslipidemia was significantly higher in participants with CRS (26.1%) than in the controls (20.6%) (p < 0.001). There was a significant positive association between CRS with/without nasal polyps and dyslipidemia (aOR = 1.36, 95%CI = 1.26-1.47, p < 0.001). The association between CRS and dyslipidemia was stronger for CRS without nasal polyps (aOR = 1.42, 95% CI = 1.28-1.57, p < 0.001) than for CRS with nasal polyps (aOR = 1.31, 95% CI = 1.17-1.47, p < 0.001). All age and sex subgroups exhibited consistent results. A personal history of dyslipidemia was associated with risk of CRS regardless of total cholesterol and the use of statins.
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