Kinetics of Serological Response in Patients with Severe Fever with Thrombocytopenia Syndromeopen access
- Authors
- Ra, Sang Hyun; Kim, Min Jae; Kim, Min-Chul; Park, Se Yoon; Park, Seong Yeon; Chong, Yong Pil; Lee, Sang-Oh; Choi, Sang-Ho; Kim, Yang Soo; Lee, Keun Hwa; Kim, Sung-Han; Kee, Sun-Ho
- Issue Date
- Jan-2021
- Publisher
- MDPI
- Keywords
- severe fever with thrombocytopenia syndrome (SFTS); viral load; immunoglobulin G (IgG); immunoglobulin M (IgM); immunofluorescence assay (IFA); enzyme-linked immunosorbent assay (ELISA)
- Citation
- VIRUSES-BASEL, v.13, no.1, pp.1 - 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- VIRUSES-BASEL
- Volume
- 13
- Number
- 1
- Start Page
- 1
- End Page
- 8
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142543
- DOI
- 10.3390/v13010006
- ISSN
- 1999-4915
- Abstract
- Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV). We investigated the detailed kinetics of serologic response in patients with SFTS. Twenty-eight patients aged >= 18 years were enrolled between July 2015 and October 2018. SFTS was confirmed by detecting SFTSV RNA in their plasma using reverse transcription polymerase chain reaction. SFTSV-specific IgG and IgM were measured using immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA). We found that SFTSV-specific IgG was detected at days 5-9 after symptom onset, and its titer was rising during the course of disease. SFTSV-specific IgM titer peaked at around week 2-3 from symptom onset. The SFTSV-specific seropositive rates for days 5-9, 10-14, 15-19, and 20-24 from symptom onset using IFA and ELISA were 63%, 76%, 90%, and 100%, and 58%, 86%, 100%, and 100%, respectively, for IgG, whereas they were 32%, 62%, 80%, and 100%, and 53%, 62%, 70%, and 100%, respectively, for IgM. The delayed IgM response could be attributed to the low sensitivity of SFTSV-specific IgM IFA or ELISA and/or impaired immune responses. The IgM test using IFA or ELISA that we used in this study is, therefore, insufficient for the early diagnosis of SFTS.
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