Axon-First Neuritogenesis on Vertical Nanowires
- Authors
- Kang, Kyungtae; Park, Yi-Seul; Park, Matthew; Jang, Min Jee; Kim, Seong-Min; Lee, Juno; Choi, Ji Yu; Jung, Da Hee; Chang, Young-Tae; Yoon, Myung-Han; Lee, Jin Seok; Nam, Yoonkey; Choi, Insung S.
- Issue Date
- Jan-2016
- Publisher
- AMER CHEMICAL SOC
- Keywords
- Silicon nanowires; neurite development; F-actin dynamics; primary hippocampal neuron; chemical vapor deposition; live-cell imaging
- Citation
- NANO LETTERS, v.16, no.1, pp.675 - 680
- Indexed
- SCIE
SCOPUS
- Journal Title
- NANO LETTERS
- Volume
- 16
- Number
- 1
- Start Page
- 675
- End Page
- 680
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/142854
- DOI
- 10.1021/acs.nanolett.5b04458
- ISSN
- 1530-6984
- Abstract
- In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.
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