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Cited 39 time in webofscience Cited 38 time in scopus
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Cytoskeletal Actin Dynamics are Involved in Pitch-Dependent Neurite Outgrowth on Bead Monolayers

Authors
Kang, KyungtaeYoon, Seo YoungChoi, Sung-EunKim, Mi-HeePark, MatthewNam, YoonkeyLee, Jin SeokChoi, Insung S
Issue Date
Jun-2014
Publisher
WILEY-V C H VERLAG GMBH
Keywords
axon outgrowth; cytoskeletal proteins; nanostructures; neurochemistry; silica beads
Citation
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.53, no.24, pp.6075 - 6079
Indexed
SCIE
SCOPUS
Journal Title
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume
53
Number
24
Start Page
6075
End Page
6079
URI
https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143364
DOI
10.1002/anie.201400653
ISSN
1433-7851
Abstract
Neurite outgrowth is an important preceding step for the development of nerve systems. Given that the in vivo environments of neurons consist of numerous hierarchical micro/nanotopographies, there have been many efforts to investigate the relationship between neuronal behaviors and surface topography. The acceleration of neurite outgrowth was recently reported on surfaces with a periodic nanotopography, but the biological mechanism has not yet been elucidated. In this work, the initial neurite development of hippocampal neurons on assembled silica beads with diameters ranging from 700 to 1800 nm was explored. The acceleration of neurite outgrowth increased with the surface-pitch size and leveled off after a pitch of 1 mm. Biochemical analysis indicated that cytoskeletal actin dynamics were primarily responsible for the recognition of surface topography. This work contributes to the emerging research field of topographical neurochemistry, as well as applied fields including neuroregeneration and neuroprosthetics.
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