Highly selective ratiometric fluorescent probe for Au3+ and its application to bioimaging
- Authors
- Choi, Ji Young; Kim, Gun-Hee; Guo, Zhiqian; Lee, Hye Yeon; Swamy, K. M. K.; Pai, Jaeyoung; Shin, Seunghoon; Shin, Injae; Yoon, Juyoung
- Issue Date
- Nov-2013
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Keywords
- Au3+ sensing; Fluorescent probe; Cell imaging; Lipid droplet; Naphthalimide
- Citation
- BIOSENSORS & BIOELECTRONICS, v.49, pp.438 - 441
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSENSORS & BIOELECTRONICS
- Volume
- 49
- Start Page
- 438
- End Page
- 441
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143660
- DOI
- 10.1016/j.bios.2013.05.033
- ISSN
- 0956-5663
- Abstract
- The 4-propargylamino-1,8-naphthalimide based fluorescent probe 1 has been explored as a sensor for selective detection of Au3+. 4-Amino-1,8-naphthalimides, that possess typical intramolecular charge transfer (ICT) electronic characteristics, have been widely used as versatile platforms for fluorescent probes. The newly designed probe 1 contains a propargylamine moiety at C-4 of the naphthalimide chromophore that reacts with Au3+ to generate a product that has distinctly different electronic properties from 1. Specifically, the probe undergoes a remarkable change in its absorption spectrum upon addition of Au3+ that is associated with a distinct color change from yellow to light pink. In addition, a blue shift of ca. 56 nm also takes place in the emission spectra of the probe. Consequently, I serves as a reaction-based sensor or so called chemodosimeter for Au3+. Importantly, surfactants enhance the rate of reaction of 1 with Au3+, thus, enhancing its use as a real time sensor. Finally, the results of studies probing its application to bioimaging of Au3+ in live cells show that the probe 1 has a unique ability to sense Au3+ in cells and, in particular, in lipid droplets within cells. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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