PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY
DC Field | Value | Language |
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dc.contributor.author | Kim, Young-Pil | - |
dc.contributor.author | Shon, Hyun Kyong | - |
dc.contributor.author | Shin, Seung Koo | - |
dc.contributor.author | Lee, Tae Geol | - |
dc.date.accessioned | 2022-07-07T07:37:19Z | - |
dc.date.available | 2022-07-07T07:37:19Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 0277-7037 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143795 | - |
dc.description.abstract | Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for label-free drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Young-Pil | - |
dc.identifier.doi | 10.1002/mas.21437 | - |
dc.identifier.scopusid | 2-s2.0-84923083996 | - |
dc.identifier.wosid | 000349223100010 | - |
dc.identifier.bibliographicCitation | MASS SPECTROMETRY REVIEWS, v.34, no.2, pp.237 - 247 | - |
dc.relation.isPartOf | MASS SPECTROMETRY REVIEWS | - |
dc.citation.title | MASS SPECTROMETRY REVIEWS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 237 | - |
dc.citation.endPage | 247 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Spectroscopy | - |
dc.relation.journalWebOfScienceCategory | Spectroscopy | - |
dc.subject.keywordPlus | SELF-ASSEMBLED MONOLAYERS | - |
dc.subject.keywordPlus | SURFACE AMINE GROUPS | - |
dc.subject.keywordPlus | TOF-SIMS | - |
dc.subject.keywordPlus | CHEMICAL-ANALYSIS | - |
dc.subject.keywordPlus | MULTIVARIATE-ANALYSIS | - |
dc.subject.keywordPlus | QUANTITATIVE-ANALYSIS | - |
dc.subject.keywordPlus | IMMOBILIZED PROTEIN | - |
dc.subject.keywordPlus | OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | GOLD NANOPARTICLES | - |
dc.subject.keywordPlus | YIELD ENHANCEMENT | - |
dc.subject.keywordAuthor | TOF-SIMS | - |
dc.subject.keywordAuthor | nanoparticle | - |
dc.subject.keywordAuthor | biomolecule | - |
dc.subject.keywordAuthor | mass imaging | - |
dc.subject.keywordAuthor | surface characterization | - |
dc.subject.keywordAuthor | signal enhancement | - |
dc.identifier.url | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mas.21437 | - |
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