PROBING NANOPARTICLES AND NANOPARTICLE-CONJUGATED BIOMOLECULES USING TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY
- Authors
- Kim, Young-Pil; Shon, Hyun Kyong; Shin, Seung Koo; Lee, Tae Geol
- Issue Date
- Mar-2015
- Publisher
- WILEY-BLACKWELL
- Keywords
- TOF-SIMS; nanoparticle; biomolecule; mass imaging; surface characterization; signal enhancement
- Citation
- MASS SPECTROMETRY REVIEWS, v.34, no.2, pp.237 - 247
- Indexed
- SCIE
SCOPUS
- Journal Title
- MASS SPECTROMETRY REVIEWS
- Volume
- 34
- Number
- 2
- Start Page
- 237
- End Page
- 247
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/143795
- DOI
- 10.1002/mas.21437
- ISSN
- 0277-7037
- Abstract
- Bio-conjugated nanoparticles have emerged as novel molecular probes in nano-biotechnology and nanomedicine and chemical analyses of their surfaces have become challenges. The time-of-flight (TOF) secondary ion mass spectrometry (SIMS) has been one of the most powerful surface characterization techniques for both nanoparticles and biomolecules. When combined with various nanoparticle-based signal enhancing strategies, TOF-SIMS can probe the functionalization of nanoparticles as well as their locations and interactions in biological systems. Especially, nanoparticle-based SIMS is an attractive approach for label-free drug screening because signal-enhancing nanoparticles can be designed to directly measure the enzyme activity. The chemical-specific imaging analysis using SIMS is also well suited to screen nanoparticles and nanoparticle-biomolecule conjugates in complex environments. This review presents some recent applications of nanoparticle-based TOF-SIMS to the chemical analysis of complex biological systems.
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