Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment
DC Field | Value | Language |
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dc.contributor.author | Park, Jun-Hong | - |
dc.contributor.author | Hwang, Il-Tae | - |
dc.contributor.author | Yang, Seung | - |
dc.date.accessioned | 2022-07-07T09:53:07Z | - |
dc.date.available | 2022-07-07T09:53:07Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2287-1012 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144286 | - |
dc.description.abstract | Purpose: This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether -202 A/C IGF binding protein-3 (IGFBP-3) promoter polymorphism affects growth velocity in females with central precocious puberty (CPP) during treatment. Methods: Data was collected from 97 females younger than 9 years, diagnosed with precocious puberty and treated with GnRHa for at least 1 year at Kangdong Sacred Heart Hospital from 2014 to 2015. Their body height, weight, change in height standard deviation score (Delta SDS), serum IGF-1, serum IGFBP-3, bone age, and -202 A/C IGFBP-3 promoter polymorphism were measured before and after GnRHa treatment. The interrelationships between the variables were calculated. Results: During treatment, height SDS, IGF-1 SDS, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio significantly decreased. A significant correlation was observed between Delta IGF-1 SDS and Delta height SDS (r=0.405, P<0.001). The presence of the C allele was significantly correlated with IGF-1 SDS after treatment (P=0.049) and with IGFBP-3 SDS before and after treatment (P= 0.012 and P=0.001), but not with Delta IGF-1 SDS, Delta IGFBP-3 SDS, Delta IGF-1/IGFBP-3 ratio, or Delta height SDS. Conclusion: Growth velocity during GnRHa treatment is related to Delta IGF-1 SDS, indicating the apparent impact of GnRHa on the GH-IGF-1 axis. The -202 A/C IGFBP-3 promoter polymorphism does not affect the growth velocity of GnRHa in CPP girls. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC PEDIATRIC ENDOCRINOLOGY | - |
dc.title | Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yang, Seung | - |
dc.identifier.doi | 10.6065/apem.2040020.010 | - |
dc.identifier.scopusid | 2-s2.0-85099049423 | - |
dc.identifier.wosid | 000605278100005 | - |
dc.identifier.bibliographicCitation | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.25, no.4, pp.234 - 239 | - |
dc.relation.isPartOf | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.title | ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | - |
dc.citation.volume | 25 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 234 | - |
dc.citation.endPage | 239 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | CENTRAL PRECOCIOUS PUBERTY | - |
dc.subject.keywordPlus | SERUM-LEVELS | - |
dc.subject.keywordPlus | ADULT HEIGHT | - |
dc.subject.keywordPlus | HORMONE ANALOG | - |
dc.subject.keywordPlus | FINAL HEIGHT | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | GIRLS | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Precocious puberty | - |
dc.subject.keywordAuthor | Growth velocity | - |
dc.subject.keywordAuthor | Insulin-like growth factor-1 | - |
dc.subject.keywordAuthor | Insulin-like growth factor binding protein-3 | - |
dc.subject.keywordAuthor | -202 A/C IGFBP-3 | - |
dc.subject.keywordAuthor | Promoter regions | - |
dc.identifier.url | https://e-apem.org/journal/view.php?doi=10.6065/apem.2040020.010 | - |
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