Relationship between growth velocity and change of levels of insulin-like growth factor-1, insulin-like growth factor binding protein-3 and, IGFBP-3 promoter polymorphism during GnRH agonist treatmentopen access
- Authors
- Park, Jun-Hong; Hwang, Il-Tae; Yang, Seung
- Issue Date
- Dec-2020
- Publisher
- KOREAN SOC PEDIATRIC ENDOCRINOLOGY
- Keywords
- Precocious puberty; Growth velocity; Insulin-like growth factor-1; Insulin-like growth factor binding protein-3; -202 A/C IGFBP-3; Promoter regions
- Citation
- ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, v.25, no.4, pp.234 - 239
- Indexed
- SCOPUS
- Journal Title
- ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Volume
- 25
- Number
- 4
- Start Page
- 234
- End Page
- 239
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144286
- DOI
- 10.6065/apem.2040020.010
- ISSN
- 2287-1012
- Abstract
- Purpose: This study aims to investigate the effect of gonadotropin-releasing hormone agonist (GnRHa) on the growth hormone (GH)-insulin-like growth factor-1 (IGF-1) axis and to evaluate whether -202 A/C IGF binding protein-3 (IGFBP-3) promoter polymorphism affects growth velocity in females with central precocious puberty (CPP) during treatment.
Methods: Data was collected from 97 females younger than 9 years, diagnosed with precocious puberty and treated with GnRHa for at least 1 year at Kangdong Sacred Heart Hospital from 2014 to 2015. Their body height, weight, change in height standard deviation score (Delta SDS), serum IGF-1, serum IGFBP-3, bone age, and -202 A/C IGFBP-3 promoter polymorphism were measured before and after GnRHa treatment. The interrelationships between the variables were calculated.
Results: During treatment, height SDS, IGF-1 SDS, IGFBP-3 SDS, and IGF-1/IGFBP-3 ratio significantly decreased. A significant correlation was observed between Delta IGF-1 SDS and Delta height SDS (r=0.405, P<0.001). The presence of the C allele was significantly correlated with IGF-1 SDS after treatment (P=0.049) and with IGFBP-3 SDS before and after treatment (P= 0.012 and P=0.001), but not with Delta IGF-1 SDS, Delta IGFBP-3 SDS, Delta IGF-1/IGFBP-3 ratio, or Delta height SDS.
Conclusion: Growth velocity during GnRHa treatment is related to Delta IGF-1 SDS, indicating the apparent impact of GnRHa on the GH-IGF-1 axis. The -202 A/C IGFBP-3 promoter polymorphism does not affect the growth velocity of GnRHa in CPP girls.
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