Phenotypic effect of botulinum toxin A on Caenorhabditis elegans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Lee, Sun-Kyung | - |
dc.contributor.author | Ahnn, Joohong | - |
dc.date.accessioned | 2022-07-07T13:35:07Z | - |
dc.date.available | 2022-07-07T13:35:07Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144649 | - |
dc.description.abstract | Botulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin type A (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect of the toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soil nematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, and locomotion while they were normal in developmental process. Worms' susceptibility to BoTX/A suggests potential utility for the assay of BoTX/A. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Phenotypic effect of botulinum toxin A on Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahnn, Joohong | - |
dc.identifier.doi | 10.1080/19768354.2014.915883 | - |
dc.identifier.scopusid | 2-s2.0-84902873551 | - |
dc.identifier.wosid | 000337965500002 | - |
dc.identifier.bibliographicCitation | ANIMAL CELLS AND SYSTEMS, v.18, no.3, pp.172 - 177 | - |
dc.relation.isPartOf | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.title | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 177 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001882903 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | NEUROTOXIN TYPES | - |
dc.subject.keywordPlus | SNAP-25 | - |
dc.subject.keywordPlus | PROTEOLYSIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordAuthor | botulinum toxin | - |
dc.subject.keywordAuthor | SNAP-25 | - |
dc.subject.keywordAuthor | Caenorhabditis elegans | - |
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