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Phenotypic effect of botulinum toxin A on Caenorhabditis elegans

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dc.contributor.authorKim, Dong-Wan-
dc.contributor.authorLee, Sun-Kyung-
dc.contributor.authorAhnn, Joohong-
dc.date.accessioned2022-07-07T13:35:07Z-
dc.date.available2022-07-07T13:35:07Z-
dc.date.created2021-05-12-
dc.date.issued2014-06-
dc.identifier.issn1976-8354-
dc.identifier.urihttps://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144649-
dc.description.abstractBotulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin type A (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect of the toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soil nematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, and locomotion while they were normal in developmental process. Worms' susceptibility to BoTX/A suggests potential utility for the assay of BoTX/A.-
dc.language영어-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titlePhenotypic effect of botulinum toxin A on Caenorhabditis elegans-
dc.typeArticle-
dc.contributor.affiliatedAuthorAhnn, Joohong-
dc.identifier.doi10.1080/19768354.2014.915883-
dc.identifier.scopusid2-s2.0-84902873551-
dc.identifier.wosid000337965500002-
dc.identifier.bibliographicCitationANIMAL CELLS AND SYSTEMS, v.18, no.3, pp.172 - 177-
dc.relation.isPartOfANIMAL CELLS AND SYSTEMS-
dc.citation.titleANIMAL CELLS AND SYSTEMS-
dc.citation.volume18-
dc.citation.number3-
dc.citation.startPage172-
dc.citation.endPage177-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001882903-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaZoology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalWebOfScienceCategoryZoology-
dc.subject.keywordPlusNEUROTOXIN TYPES-
dc.subject.keywordPlusSNAP-25-
dc.subject.keywordPlusPROTEOLYSIS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCOMPLEXES-
dc.subject.keywordAuthorbotulinum toxin-
dc.subject.keywordAuthorSNAP-25-
dc.subject.keywordAuthorCaenorhabditis elegans-
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