Phenotypic effect of botulinum toxin A on Caenorhabditis elegansopen access
- Authors
- Kim, Dong-Wan; Lee, Sun-Kyung; Ahnn, Joohong
- Issue Date
- Jun-2014
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- botulinum toxin; SNAP-25; Caenorhabditis elegans
- Citation
- ANIMAL CELLS AND SYSTEMS, v.18, no.3, pp.172 - 177
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ANIMAL CELLS AND SYSTEMS
- Volume
- 18
- Number
- 3
- Start Page
- 172
- End Page
- 177
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/144649
- DOI
- 10.1080/19768354.2014.915883
- ISSN
- 1976-8354
- Abstract
- Botulinum toxins (BoTXs) are potent inhibitors of neurotransmission mediated by exocytosis, cleaving synaptosomal-associated protein of 25 kDa (SNAP-25) to cause paralysis and death in human. Among them, botulinum toxin type A (BoTX/A) is both clinically and cosmetically important because of its wide application in clinical and cosmetic treatment. Therefore, development of feasible and effective model-base assay system might be very helpful to understand the effect of the toxin. In this study, we have examined the physiological effect of BoTX/A on Caenorhabditis elegans, a free-living soil nematode model system. Worms treated with BoTX/A showed defective egg-laying, yolk protein consumption, and locomotion while they were normal in developmental process. Worms' susceptibility to BoTX/A suggests potential utility for the assay of BoTX/A.
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