Loss of ASXL1 expression is associated with lymph node metastasis in colorectal cancer
- Authors
- Lee, Jun Ho; Lee, Ju-Hee; Ahn, Byung kyu; Paik, Seung Sam; Kim, Hyunsung; Lee, Kang Hong
- Issue Date
- Apr-2020
- Publisher
- WOLTERS KLUWER MEDKNOW PUBLICATIONS
- Keywords
- ASXL1; colorectal cancer; lymph node; metastasis; prognosis
- Citation
- INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, v.63, no.2, pp.221 - 225
- Indexed
- SCIE
SCOPUS
- Journal Title
- INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY
- Volume
- 63
- Number
- 2
- Start Page
- 221
- End Page
- 225
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/145909
- DOI
- 10.4103/IJPM.IJPM_822_19
- ISSN
- 0377-4929
- Abstract
- Context: The function of ASXL1 in colorectal cancer (CRC) has not been investigated yet.
Aims: The purpose of this study was to investigate the clinicopathological and prognostic impact of ASXL1 expression on CRC.
Settings and Design: The intensity of expression was scored as 0-3, and the extent of staining was scored as 0-4, based on the percentage of positive cells. The immunoreactivity score (IRS) was calculated by multiplying the two scores.
Materials and Methods: We performed immunohistochemical staining of ASXL1 using tissue microarrays of 408 CRCs, 46 normal colonic mucosae, 48 adenomas, and 92 metastatic lymph nodes.
Statistical Analysis Used: Clinicopathological variables were compared using Fisher's exact test, χ2-test, or unpaired Student's t-test, depending on the nature of the data.
Results: A negative expression of ASXL1 was observed in 10.9% of normal mucosae, 27.1% of adenomas, 55.6% of adenocarcinomas, and 71.7% of metastatic lymph nodes (P < 0.001). With respect to the IRS cut-off score, lymph node metastasis and lymphatic invasion were more frequent in the IRS 0-6 group than in the IRS 8-12 group (56.3% vs. 33.3%, P = 0.034; 56.0% vs. 33.3%, P = 0.035). The 5-year disease-free survival rate was significantly lower in patients with IRS 0-6 group than those with IRS 8-12 group (78.7 ± 2.5 vs. 100%, P = 0.034).
Conclusion: ASXL1 might act as a tumor suppressor in CRC. The loss of ASXL1 expression might be associated with lymph node metastasis and lymphatic invasion in CRC.
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