Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders
- Authors
- Das, Soumyadip; Ramakrishna, Suresh; Kim, Kye-Seong
- Issue Date
- Mar-2020
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- Alzheimer's disease; deubiquitinating enzyme inhibitors; epilepsy; neural stem cells; Parkinson's disease
- Citation
- MOLECULES AND CELLS, v.43, no.3, pp 203 - 214
- Pages
- 12
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- MOLECULES AND CELLS
- Volume
- 43
- Number
- 3
- Start Page
- 203
- End Page
- 214
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146062
- DOI
- 10.14348/molcells.2020.2289
- ISSN
- 1016-8478
0219-1032
- Abstract
- Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity, axonal growth, and proper function of the nervous system. Moreover, mutations or downregulation of certain DUBs have been found in several neurodegenerative diseases, as well as gliomas and neuroblastomas. Based on emerging findings, DUBs represent an important target for therapeutic intervention in various neurological disorders. Here, we summarize advances in our understanding of the roles of DUBs related to neurobiology.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 의생명공학전문대학원 > 서울 의생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146062)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.