Outcome of breast-conserving treatment for axillary lymph node metastasis from occult breast cancer with negative breast MRIopen access
- Authors
- Kim, Haeyoung; Park, Won; Kim, Su Ssan; Ahn, Sung Ja; Kim, Yong Bae; Kim, Tae Hyun; Kim, Jin Hee; Choi, Jin-Hwa; Park, Hae Jin; Chang, Jee Suk; Choi, Doo Ho
- Issue Date
- Feb-2020
- Publisher
- CHURCHILL LIVINGSTONE
- Keywords
- Neoplasms; Unknown primary; Breast neoplasm; Lymph nodes; Magnetic resonance imaging; Radiotherapy
- Citation
- BREAST, v.49, pp.63 - 69
- Indexed
- SCIE
SCOPUS
- Journal Title
- BREAST
- Volume
- 49
- Start Page
- 63
- End Page
- 69
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146208
- DOI
- 10.1016/j.breast.2019.10.017
- ISSN
- 0960-9776
- Abstract
- Purpose: We conducted this study to investigate the prognosis and failure pattern after breast-conserving treatment (BCT) in patients with occult breast cancer (OBC) with negative breast magnetic resonance imaging (MRI) (MRI-OBC).
Materials and methods: Survival rates and failure patterns in 66 patients who received axillary lymph node dissection (ALND) and BCT for MRI-OBC between 2001 and 2013 at seven hospitals were analyzed. OBC was defined as adenocarcinoma in the axillary lymph node (ALN) +/- supraclavicular (SCN) or internal mammary lymph node (IMN) with a negative breast MRI.
Results: Fifty-four patients had only ALN metastasis (ALN only), and 12 patients had ALN metastasis along with SCN or IMN metastasis (ALN + SCN/IMN). Median follow-up was 82 months. The 5-year overall, disease-free, and breast cancer-free survival rates were 93.4%, 92.1%, and 96.8%, respectively. Nine patients experienced recurrence: breast (n = 4), regional lymph nodes (RLN, n = 1), distant metastases (DM, n = 2), breast/RLN (n = 1), and breast/RLN/DM (n = 1). Five-year disease-free survival was significantly higher in ALN only patients compared to ALN + SCN/IMN patients (96.1% vs. 75.0%; p = 0.02).
Conclusions: Patients with MRI-OBC were successfully treated with BCT. There was a small risk of ipsilateral breast cancer recurrence. Failure patterns depended on the extent of initial disease.
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