Significance of skull osteoporosis to the development of peritumoral brain edema after LINAC-based radiation treatment in patients with intracranial meningiomaopen access
- Authors
- Lee, Ryang-Hun; Kim, Jae Min; Cheong, Jin Hwan; Ryu, Je Il; Kim, Young Soo; Han, Myun Hoon
- Issue Date
- Feb-2020
- Publisher
- PUBLIC LIBRARY SCIENCE
- Citation
- PLOS ONE, v.15, no.2, pp.1 - 14
- Indexed
- SCIE
SCOPUS
- Journal Title
- PLOS ONE
- Volume
- 15
- Number
- 2
- Start Page
- 1
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146268
- DOI
- 10.1371/journal.pone.0226312
- ISSN
- 1932-6203
- Abstract
- Background and purpose
Disruption of the tumor-brain barrier in meningioma plays a critical role in the development of peritumoral brain edema (PTBE). We hypothesized that osteoporotic conditions may be associated with PTBE occurrence after radiation in patients with intracranial meningioma.
Methods
We measured Hounsfield units (HU) of the frontal skull on simulation brain CT in patients who underwent linear accelerator (LINAC)-based radiation treatment for intracranial meningioma. Receiver operating characteristic curve analysis was performed to determine the optimal cut-off values for several predictive factors. The cumulative hazard for PTBE was estimated and classified according to these factors. Hazard ratios were then estimated to identify independent predictive factors associated with the development of PTBE after radiation in intracranial meningioma patients.
Results
A total of 83 intracranial meningiomas in 76 patients who received LINAC-based radiation treatment in our hospital over an approximate 5-year period were included for the study. We found mean frontal skull HU ≤630.625 and gross tumor volume >7.194 cc to be independent predictors of PTBE after radiation treatment in patients with meningioma (hazard ratio, 8.41; P = 0.019; hazard ratio, 5.92; P = 0.032, respectively). In addition, patients who were ≥65 years showed a marginally significant association with PTBE.
Conclusions
Our study suggests that possible osteoporotic conditions, large tumor volume, and older age may be associated with PTBE occurrence after LINAC-based radiation treatment for intracranial meningioma. In the future we anticipate that these findings may enhance the understanding of the underlying mechanisms of PTBE after radiation in meningioma patients.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 신경외과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146268)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.