Resting-state functional connectivity modulates the BOLD activation induced by nucleus accumbens stimulation in the swine brainopen access
- Authors
- Cho, Shinho; Hachmann, Jan T.; Balzekas, Irena; In, Myung-Ho; Andres-Beck, Lindsey G.; Lee, Kendall H.; Min, Hoon-Ki; Jo, Hang Joon
- Issue Date
- Dec-2019
- Publisher
- WILEY
- Keywords
- blood-oxygenation-level-dependent hemodynamic response; deep brain stimulation; functional connectivity change; functional magnetic resonance imaging; network effect; nucleus accumbens; resting-state functional connectivity
- Citation
- BRAIN AND BEHAVIOR, v.9, no.12, pp.1 - 17
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRAIN AND BEHAVIOR
- Volume
- 9
- Number
- 12
- Start Page
- 1
- End Page
- 17
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146644
- DOI
- 10.1002/brb3.1431
- ISSN
- 2162-3279
- Abstract
- IntroductionWhile the clinical efficacy of deep brain stimulation (DBS) the treatment of motor-related symptoms is well established, the mechanism of action of the resulting cognitive and behavioral effects has been elusive. MethodsBy combining functional magnetic resonance imaging (fMRI) and DBS, we investigated the pattern of blood-oxygenation-level-dependent (BOLD) signal changes induced by stimulating the nucleus accumbens in a large animal model. ResultsWe found that diffused BOLD activation across multiple functional networks, including the prefrontal, limbic, and thalamic regions during the stimulation, resulted in a significant change in inter-regional functional connectivity. More importantly, the magnitude of the modulation was closely related to the strength of the inter-regional resting-state functional connectivity. ConclusionsNucleus accumbens stimulation affects the functional activity in networks that underlie cognition and behavior. Our study provides an insight into the nature of the functional connectivity, which mediates activation effect via brain networks.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 생리학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/146644)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.