Adenine base editors catalyze cytosine conversions in human cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Heon Seok | - |
dc.contributor.author | Jeong, You Kyeong | - |
dc.contributor.author | Hur, Junho K. | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Bae, Sangsu | - |
dc.date.accessioned | 2022-07-09T06:40:48Z | - |
dc.date.available | 2022-07-09T06:40:48Z | - |
dc.date.created | 2021-05-11 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1087-0156 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147099 | - |
dc.description.abstract | Adenine base editors comprise an adenosine deaminase, evolved in vitro, and a Cas9 nickase. Here, we show that in addition to converting adenine to guanine, adenine base editors also convert cytosine to guanine or thymine in a narrow editing window (positions 5-7) and in a confined TC*N sequence context. Adenine base editor-induced cytosine substitutions occur independently of adenosine conversions with an efficiency of up to 11.2% and reduce the number of suitable targeting sites for high-specificity base editing. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE RESEARCH | - |
dc.title | Adenine base editors catalyze cytosine conversions in human cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Heon Seok | - |
dc.contributor.affiliatedAuthor | Hur, Junho K. | - |
dc.contributor.affiliatedAuthor | Bae, Sangsu | - |
dc.identifier.doi | 10.1038/s41587-019-0254-4 | - |
dc.identifier.scopusid | 2-s2.0-85072942908 | - |
dc.identifier.wosid | 000493315800015 | - |
dc.identifier.bibliographicCitation | Nature Biotechnology, v.37, no.10, pp.1145 - 1148 | - |
dc.relation.isPartOf | Nature Biotechnology | - |
dc.citation.title | Nature Biotechnology | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1145 | - |
dc.citation.endPage | 1148 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.subject.keywordPlus | GENOMIC DNA | - |
dc.subject.keywordPlus | TARGET | - |
dc.identifier.url | https://www.nature.com/articles/s41587-019-0254-4 | - |
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