Primary Histiocytic Sarcoma Presenting as a Breast Mass: A Case Reportopen access
- Authors
- Bang, Seongsik; Kim, Yeseul; Chung, Min Sung; Park, Jeong Seon; Choi, Yun Young; Shin, Su-Jin
- Issue Date
- Sep-2019
- Publisher
- KOREAN BREAST CANCER SOC
- Keywords
- Breast; Histiocytes; Histiocytic sarcoma; True histiocytic lymphoma
- Citation
- JOURNAL OF BREAST CANCER, v.22, no.3, pp.491 - 496
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF BREAST CANCER
- Volume
- 22
- Number
- 3
- Start Page
- 491
- End Page
- 496
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147197
- DOI
- 10.4048/jbc.2019.22.e32
- ISSN
- 1738-6756
- Abstract
- Histiocytic sarcoma is a rare hematologic malignancy, with very few cases of primary histiocytic sarcoma of the breast described in English scientific literature. Herein, we describe a case of primary histiocytic sarcoma of the breast in a 75-year-old woman, with no clinical history of malignant tumors, who presented with a palpable solitary breast mass. Microscopically, the resected breast mass showed large pleomorphic cells, some multinucleated giant cells, and admixed inflammatory components. The pleomorphic tumor cells further showed a diffuse, noncohesive growth pattern, an abundant eosinophilic cytoplasm, and strong and diffuse immunoreactivity for cluster of differentiation (CD) 68 and CD163. Furthermore, a whole-body positron-emission tomography/computed tomography using deoxy-2-[F-18] fluoro-D-glucose performed after surgery showed no other masses or lesions. After surgical excision, the patient was followed up, and no evidence of tumor recurrence or metastasis was noted.
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