Decreased Aquaporin 4 and 6 mRNAs in Patients with Chronic Otitis Media with Otorrheaopen access
- Authors
- Kim, Ji Hoon; Kim, Sung Su; Kim, Young Il; Jung, Su Young; Kim, Sang Hoon; Yeo, Seung Geun
- Issue Date
- Aug-2019
- Publisher
- KOREAN SOC OTORHINOLARYNGOL
- Keywords
- Aquaporin; Otitis Media; Middle Ear; Chronic; Discharge
- Citation
- CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, v.12, no.3, pp.267 - 272
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
- Volume
- 12
- Number
- 3
- Start Page
- 267
- End Page
- 272
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147283
- DOI
- 10.21053/ceo.2018.00472
- ISSN
- 1976-8710
- Abstract
- Objectives. Aquaporins (AQPs) are integral membrane proteins engaged in the modulation of water homeostasis, but the roles they play in chronic otitis media (COM) have not been well investigated. Accordingly, we undertook document relations between the mRNA expressions of AQPs and COM, and explored the relation between these expressions and otorrhea, which is one of the most common symptoms of COM.
Methods. Levels of the mRNAs of AQP 1, 2, 3, 4, 5, 6, 8, and 10 were assayed by real-time polymerase chain reaction in inflammatory tissue samples from 81 patients with COM with or without otorrhea. Relationships between AQP mRNA levels and the presence or absence of otorrhea, the presence or absence of bacteria, hearing threshold levels, types of hearing loss, and clinical manifestations were also evaluated.
Results. AQP 1, 2, 3, 4, 5, 6, 8, and 10 mRNAs were expressed in inflammatory tissues obtained from all 81 patients with COM with or without otorrhea. AQP 5 mRNA was most expressed in, followed in descending order by AQP 3, 1, 10, 6, 8, 2, and 4.There were no significant intergroup differences in terms of age, sex, duration of illness, levels of hearing loss in both ears, or incidences of conductive or sensorineural hearing loss. However, AQP 4 (P=0.035) and 6 (P =0 .085) mRNA levels were significantly lower in the otorrhea group. In addition, bacteria culture positivity (P=0.014) and the incidence of sensorineural hearing loss (P=0.020) were higher in the otorrhea group.
Conclusion. AQP 1, 2, 3, 4, 5, 6, 8, and 10 are involved in the development of COM. Specifically, it shows reductions in AQP 4 and 6 mRNA levels, as observed in the otorrhea group, have an effect on the clinical manifestations of COM.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 교육협력지원교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147283)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.