Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
DC Field | Value | Language |
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dc.contributor.author | Paris, Jasmin | - |
dc.contributor.author | Morgan, Marcos | - |
dc.contributor.author | Campos, Joana | - |
dc.contributor.author | Spencer, Gary J. | - |
dc.contributor.author | Shmakova, Alena | - |
dc.contributor.author | Ivanova, Ivayla | - |
dc.contributor.author | Mapperley, Christopher | - |
dc.contributor.author | Lawson, Hannah | - |
dc.contributor.author | Wotherspoon, David A. | - |
dc.contributor.author | Sepulveda, Catarina | - |
dc.contributor.author | Vukovic, Milica | - |
dc.contributor.author | Allen, Lewis | - |
dc.contributor.author | Sarapuu, Annika | - |
dc.contributor.author | Tavosanis, Andrea | - |
dc.contributor.author | Guitart, Amelie V. | - |
dc.contributor.author | Villacreces, Arnaud | - |
dc.contributor.author | Much, Christian | - |
dc.contributor.author | Choe, Junho | - |
dc.contributor.author | Azar, Ali | - |
dc.contributor.author | van de Lagemaat, Louie N. | - |
dc.contributor.author | Vernimmen, Douglas | - |
dc.contributor.author | Nehme, Ali | - |
dc.contributor.author | Mazurier, Frederic | - |
dc.contributor.author | Somervaille, Tim C. P. | - |
dc.contributor.author | Gregory, Richard I. | - |
dc.contributor.author | O'Carroll, Donal | - |
dc.contributor.author | Kranc, Kamil R. | - |
dc.date.accessioned | 2022-07-09T11:54:35Z | - |
dc.date.available | 2022-07-09T11:54:35Z | - |
dc.date.created | 2021-05-14 | - |
dc.date.issued | 2019-07 | - |
dc.identifier.issn | 1934-5909 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147406 | - |
dc.description.abstract | Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we show that the mRNA m6A reader YTHDF2 is overexpressed in a broad spectrum of human AML and is required for disease initiation as well as propagation in mouse and human AML. YTHDF2 decreases the half-life of diverse m6A transcripts that contribute to the overall integrity of LSC function, including the tumor necrosis factor receptor Tnfrsf2, whose upregulation in Ythdf2-deficient LSCs primes cells for apoptosis. Intriguingly, YTHDF2 is not essential for normal HSC function, with YTHDF2 deficiency actually enhancing HSC activity. Thus, we identify YTHDF2 as a unique therapeutic target whose inhibition selectively targets LSCs while promoting HSC expansion. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.title | Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choe, Junho | - |
dc.identifier.doi | 10.1016/j.stem.2019.03.021 | - |
dc.identifier.scopusid | 2-s2.0-85068056394 | - |
dc.identifier.wosid | 000473770700013 | - |
dc.identifier.bibliographicCitation | CELL STEM CELL, v.25, no.1, pp.137 - 148 | - |
dc.relation.isPartOf | CELL STEM CELL | - |
dc.citation.title | CELL STEM CELL | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 148 | - |
dc.type.rims | ART | - |
dc.type.docType | 정기학술지(Article(Perspective Article포함)) | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | NUCLEAR-RNA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HIF-1-ALPHA | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | N6-METHYLADENOSINE | - |
dc.subject.keywordPlus | LEUKEMOGENESIS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordAuthor | acute myeloid leukemia | - |
dc.subject.keywordAuthor | hematopoiesis | - |
dc.subject.keywordAuthor | hematopoietic stem cell | - |
dc.subject.keywordAuthor | leukemic stem cells | - |
dc.subject.keywordAuthor | m6A modification | - |
dc.subject.keywordAuthor | mRNA decay | - |
dc.subject.keywordAuthor | TNFR2 | - |
dc.subject.keywordAuthor | YTHDF2 | - |
dc.identifier.url | https://linkinghub.elsevier.com/retrieve/pii/S1934590919301201 | - |
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