Is preeclampsia itself a risk factor for the development of metabolic syndrome after delivery?open access
- Authors
- Geum Joon Cho; Un Suk Jung; Jae Young Sim; Yoo Jin Lee; Na Young Bae; Hye Jin Choi; Jong Heon Park; Hai-Joong Kim; Min-Jeong Oh
- Issue Date
- Jul-2019
- Publisher
- Korean Society of Obstetrics and Gynecology
- Keywords
- Preeclampsia; Metabolic syndrome; Cardiovascular disease; Diabetes mellitus; Hypertension
- Citation
- Obstetrics and Gynecology Science, v.62, no.4, pp.233 - 241
- Indexed
- SCOPUS
KCI
- Journal Title
- Obstetrics and Gynecology Science
- Volume
- 62
- Number
- 4
- Start Page
- 233
- End Page
- 241
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/147430
- DOI
- 10.5468/ogs.2019.62.4.233
- ISSN
- 2287-8572
- Abstract
- Objective This study aimed to determine the association between preeclampsia and the postpartum development of metabolic syndrome based on the pre-pregnancy status. Methods Korean women who delivered their first child between January 1, 2011, and December 31, 2012, were enrolled. All subjects underwent a national health screening examination conducted by the National Health Insurance Corporation 1 or 2 years prior to their first delivery and within 2 years after their first delivery. Results Among the 49,065 participants, preeclampsia developed in 3,391 participants (6.9%). The prevalence of metabolic syndrome was higher postpartum in women with preeclampsia than in those without preeclampsia (4.9% vs. 2.7%, respectively, P < 0.001). Through the pre-pregnancy to postpartum period, women with preeclampsia had a greater increase in gestational weight retention, body mass index, waist circumference, systolic blood pressure, and triglyceride levels and a greater decrease in high-density lipoprotein cholesterol levels than women without preeclampsia. Preeclampsia was associated with an increased risk of the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome (odds ratio, 1.28; 95% confidence interval, 1.05-1.56). However, preeclampsia was not associated with postpartum metabolic syndrome in women with pre-pregnancy metabolic syndrome or 2 components of metabolic syndrome. Conclusion In this study, preeclampsia was associated with the postpartum development of metabolic syndrome in women without pre-pregnancy metabolic syndrome. However, the effects were attenuated by predisposing risk factors in the pre-pregnancy period. ? 2019 Korean Society of Obstetrics and Gynecology.
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