Respiratory syncytial virus-associated seizures in Korean children, 2011–2016open access
- Authors
- Cha, Teahyen; Choi, Young Jin; Oh, Jae Won; Kim, Chang-Ryul; Park, Dong Woo; Seol, In Joon; Moon, Jin Hwa
- Issue Date
- Apr-2019
- Publisher
- Korean Pediatric Society
- Keywords
- Respiratory syncytial virus; Child; Seizure; Magnetic resonance imaging
- Citation
- Korean Journal of Pediatrics, v.62, no.4, pp.131 - 137
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Pediatrics
- Volume
- 62
- Number
- 4
- Start Page
- 131
- End Page
- 137
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148006
- DOI
- 10.3345/kjp.2018.07066
- ISSN
- 1738-1061
- Abstract
- Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that present with seizures. Methods: We retrospectively reviewed the medical records of patients aged less than 15 years with laboratory-confirmed RSV infections and seizures between January 2011 and December 2016 in a regional hospital in South Korea. Results: During this period, 1,193 patients with laboratory-confirmed RSV infection were identified. Of these, 35 (35 of 1,193, 2.93%; boys, 19; girls, 16; mean age: 20.8±16.6 months) presented with seizure. Febrile seizure was the most common diagnosis (27 of 35, 77.1%); simple febrile seizures in 13 patients (13 of 27, 48.1%) and complex febrile seizures in 14 (14 of 27, 51.9%). Afebrile seizures without meningitis or encephalopathy were observed in 5 patients (5 of 35, 14.3%), seizures with meningitis in 2 (2 of 35, 5.7%), and seizure with encephalopathy in 1 (1 of 35, 2.9%) patient. Lower respiratory symptoms were not observed in 8 patients. In a patient with encephalopathy, brain diffusion-weighted magnetic resonance imaging revealed transient changes in white matter, suggesting cytotoxic edema as the mechanism underlying encephalopathy. Most patients recovered with general management, and progression to epilepsy was noted in only 1 patient. Conclusion: Although febrile seizures are the most common type of seizure associated with RSV infection, the proportion of patients with complex febrile seizures was higher than that of those with general febrile seizures. Transient cytotoxic edema may be a pathogenic mechanism in RSV-related encephalopathy with seizures.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 영상의학교실 > 1. Journal Articles
- 서울 의과대학 > 서울 소아청소년과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148006)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.