Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysateopen access
- Authors
- Park, Eun-Ah; Hang, Ik-Hwan; Kim, Jung-Hyun; Park, Soon-Jung; Ryu, Jae-Sook; Ahn, Myoung-Hee
- Issue Date
- Apr-2019
- Publisher
- KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
- Keywords
- Toxoplasma gondii; mast cell; cytokine; nitric oxide
- Citation
- KOREAN JOURNAL OF PARASITOLOGY, v.57, no.2, pp 201 - 206
- Pages
- 6
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- KOREAN JOURNAL OF PARASITOLOGY
- Volume
- 57
- Number
- 2
- Start Page
- 201
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148042
- DOI
- 10.3347/kjp.2019.57.2.201
- ISSN
- 0023-4001
1738-0006
- Abstract
- The roles of mast cells in allergic diseases and helminth infections are well known. However, the roles of mast cells in T. gondii infection is poorly understood. This study was focused on the production of pro-inflammatory cytokines (TNF-alpha, IL-4), chemokines (CXCL8, MCP-1) and nitric oxide (NO) by mast cells in response to soluble lysate of T. gondii tachyzoites. Production of CXCL8 (IL-8), MCP-1, TNF-alpha and IL-4 were measured by RT-PCR and ELISA. Western blot were used for detection of CXCR-1 and CXCR2. Our results showed that T. gondii lysates triggered mast cells to release CXCL8, MCP-1, TNF-alpha, IL-4 and to produce NO. This suggests that mast cells play an important role in inflammatory responses to T. gondii.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 환경의생물학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148042)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.