Risk Factors for Nephrocalcinosis in Very Low Birth Weight Infantsopen access
- Authors
- 한상은; 차태현; 김진서; 김자혜; 김창렬; 박현경; 이현주
- Issue Date
- Mar-2019
- Publisher
- 대한주산의학회
- Keywords
- Nephrocalcinosis; Prematurity; Very low birth weight; Risk factors
- Citation
- Perinatology, v.30, no.1, pp.14 - 19
- Indexed
- KCI
- Journal Title
- Perinatology
- Volume
- 30
- Number
- 1
- Start Page
- 14
- End Page
- 19
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148272
- DOI
- 10.14734/PN.2019.30.1.14
- ISSN
- 2508-4887
- Abstract
- Objective: The objective was to identify risk factors for nephrocalcinosis in very low birth weight (VLBW) infants.
Methods: Prospective study has done between 2014 and 2017. The study included 81 VLBW infants in the neonatal intensive care unit (NICU). Renal ultrasonography was performed at four weeks and 3 months. Baseline characteristics, complications and medication during NICU admission were collected.
25-(OH)-vitamin D, calcium, phosphorous, alkaline phosphatase, urine calcium to creatinine ratio were serially measured.
Results: The incidence of nephrocalcinosis was 16.9%. On univariate analysis, gestational age, lower birth weight, maternal pregnancy-induced hypertension, neonatal sepsis, and frequency of vancomycin and caffeine citrate treatment were significantly associated with nephrocalcinosis. In addition, preterm infants with nephrocalcinosis had lower cord blood 25-(OH)-vitamin D and serum calcium levels and higher serum alkaline phosphatase levels at 2 weeks of life. Multivariate analysis showed that gestational age (P=0.042), birth weight (P=0.019), sepsis (P=0.046), small for gestational age (P=0.015), and maternal pregnancy-induced hypertension (P=0.024) were significant risk factors for nephrocalcinosis.
Conclusion: This study suggests that neonatal sepsis and maternal pregnancy-induced hypertension, in addition to gestational age and birth weight are important perinatal risk factors for nephrocalcinosis.
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