Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
- Authors
- Kim, Mee Kyoung; Han, Kyungdo; Koh, Eun Sil; Kim, Eun Sook; Lee, Min-Kyung; Nam, Ga Eun; Kwon, Hyuk-Sang
- Issue Date
- Feb-2019
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- blood pressure; cardiovascular diseases; diabetes mellitus; hypertension; Korea
- Citation
- HYPERTENSION, v.73, no.2, pp.319 - 326
- Indexed
- SCIE
SCOPUS
- Journal Title
- HYPERTENSION
- Volume
- 73
- Number
- 2
- Start Page
- 319
- End Page
- 326
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148378
- DOI
- 10.1161/HYPERTENSIONAHA.118.12160
- ISSN
- 0194-911X
- Abstract
- The objective of this study was to investigate the optimal blood pressure (BP) target to prevent development of cardiovascular diseases (CVDs) in Korean subjects with type 2 diabetes mellitus. Using the Korean National Health Insurance Service database, 2 262 725 subjects with type 2 diabetes mellitus who underwent regular health checks between 2009 and 2012 were included. Subjects with previous CVDs were excluded. Participants were grouped by 10-mm Hg intervals of observed systolic BP (SBP) by 5-mm Hg intervals of diastolic BP. There were 124 466 deaths (5.50%), 67 235 cases of stroke (2.97%), and 41 726 myocardial infarctions (1.84%) during a median follow-up of 6.5 years. Compared with SBP 110 to 119 mm Hg, there was no increased risk among subjects with SBP 120 to 129 mm Hg, but SBP ≥130 mm Hg was associated with a significant increase in the incidence of CVDs. SBP 130 to 139 mm Hg was associated with a significant increase in the incidence of stroke (hazard ratio, 1.15; 95% CI, 1.12–1.18) and myocardial infarctions (hazard ratio, 1.05; 95% CI, 1.02–1.09) compared with SBP 110 to 119 mm Hg. Subjects with diastolic BP 80 to 84 mm Hg had a higher risk of CVDs than subjects with diastolic BP 75 to 79 mm Hg. The overall relationship between BP and CVD risk was positive, with a greater strength observed for younger age groups. The optimal cutoff for Korean patients with type 2 diabetes mellitus associated with lower CVD risk may be 130 mm Hg for SBP or 80 mm Hg for diastolic BP.
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