Depressive Disorder in Thyroid Cancer Patients after Thyroidectomy: A Longitudinal Follow-up Study Using a National Cohort
- Authors
- Choi, Hyo Geun; Park, Bumjung; Ji, Yong Bae; Tae, Kyung; Song, Chang Myeon
- Issue Date
- Feb-2019
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- thyroid cancer; thyroidectomy; depression; epidemiology; mood disorder; cohort study; case-control study
- Citation
- OTOLARYNGOLOGY-HEAD AND NECK SURGERY, v.160, no.2, pp.239 - 245
- Indexed
- SCIE
SCOPUS
- Journal Title
- OTOLARYNGOLOGY-HEAD AND NECK SURGERY
- Volume
- 160
- Number
- 2
- Start Page
- 239
- End Page
- 245
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148416
- DOI
- 10.1177/0194599818802190
- ISSN
- 0194-5998
- Abstract
- Objective The present study compared the frequency of depressive disorder in patients with thyroid cancer who had undergone thyroidectomy with the frequency in control individuals. Study Design Retrospective population-based cohort study. Setting This study used data from the Korean Health Insurance Review and Assessment Service-National Sample Cohort. Subject and Methods A total of 3609 participants with thyroid cancer who had undergone thyroidectomy between 2003 and 2011 were enrolled in this study and matched 1:4 with 14,436 control participants by age, sex, income, and region of residence. The cumulative incidence of postoperative depressive disorder was evaluated over a period of 10 years after the thyroidectomies and compared with the incidence in controls. Depressive disorder was diagnosed by a psychiatrist. Results The incidence of depressive disorder was significantly higher in the thyroid cancer with thyroidectomy group than in the controls up to postoperative year 1. A subgroup analysis showed the same higher incidence of depressive disorder in the thyroid cancer group than controls for up to 1 year after operations in young adult (<= 44 years old), female, urban, and low-income groups. However, the incidence was elevated only in the year of the thyroidectomies themselves in middle-aged and older, rural, and high-income groups. Conclusion Patients with thyroid cancer who undergo thyroidectomy have depressive disorder more frequently than normal controls. However, the frequency of depressive disorder after thyroidectomy recovers in a shorter period in middle-aged or older, high-income, and rural-dwelling patients, compared to younger, low-income, and urban-dwelling patients.
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