Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model
DC Field | Value | Language |
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dc.contributor.author | Lee, Su Mi | - |
dc.contributor.author | Lee, Mi Hwa | - |
dc.contributor.author | Son, Young Ki | - |
dc.contributor.author | Kim, Seong Eun | - |
dc.contributor.author | Park, Yongsoon | - |
dc.contributor.author | Rha, Seo Hee | - |
dc.contributor.author | An, Won Suk | - |
dc.date.accessioned | 2022-07-10T14:55:40Z | - |
dc.date.available | 2022-07-10T14:55:40Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 0886-022X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148517 | - |
dc.description.abstract | Aim: Stearoyl-CoA desaturase (SCD)-1 and elongase-6 (Elovl-6) are associated with fatty acid (FA) synthesis. We evaluated the effect of omega-3 FA on erythrocyte membrane FA contents through SCD-1 and Elovl-6 expression in the liver and kidney of a cyclosporine (CsA)-induced rat model. Methods: Male Sprague Dawley rats were divided into control, CsA, and CsA treated with omega-3 FA groups. We measured SCD-1 and Elovl-6 expression levels via western blot and immunohistochemistry analysis. Results: Erythrocyte membrane oleic acid content was lower in the CsA with omega-3 FA group compared to the CsA group. Compared to the control group, CsA-induced rats showed elevated SCD-1 expression in the kidney and liver, which omega-3 FA treatment reversed. Elovl-6 expression was increased in the liver, but decreased in the kidney in CsA group compared to control, which omega-3 FA treatment also reversed. Conclusions: Omega-3 FA supplementation decreased erythrocyte membrane oleic acid content by modulating SCD-1 and Elovl-6 expression in the kidney and liver of CsA-induced rats. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Omega-3 fatty acid decreases oleic acid by decreasing SCD-1 expression in the liver and kidney of a cyclosporine-induced nephropathy rat model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.identifier.doi | 10.1080/0886022X.2019.1591996 | - |
dc.identifier.scopusid | 2-s2.0-85064239050 | - |
dc.identifier.wosid | 000463350900001 | - |
dc.identifier.bibliographicCitation | RENAL FAILURE, v.41, no.1, pp.211 - 219 | - |
dc.relation.isPartOf | RENAL FAILURE | - |
dc.citation.title | RENAL FAILURE | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 219 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | STEAROYL-COA DESATURASE | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | ELONGASE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | COENZYME | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | DISRUPTION | - |
dc.subject.keywordAuthor | Cyclosporine | - |
dc.subject.keywordAuthor | fatty acid | - |
dc.subject.keywordAuthor | kidney | - |
dc.subject.keywordAuthor | liver | - |
dc.subject.keywordAuthor | omega-3 | - |
dc.subject.keywordAuthor | oleic acid | - |
dc.identifier.url | https://www.scopus.com/record/display.uri?eid=2-s2.0-85064239050&origin=inward&txGid=aca24f788d8b514d4d33559a6851d50c | - |
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