Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Kibeum | - |
dc.contributor.author | Yoon, Hyo-Jung | - |
dc.contributor.author | Imm, Jee-Young | - |
dc.contributor.author | Go, Gwang-woong | - |
dc.date.accessioned | 2022-07-10T14:57:40Z | - |
dc.date.available | 2022-07-10T14:57:40Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1096-620X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/148564 | - |
dc.description.abstract | The effects of dietary supplementation with aqueous Hovenia dulcis Thunb. extract (HDE) (20 weeks) on high-fat diet (HFD)-induced nonalcoholic fatty liver disease and dyslipidemia were evaluated in mice. Supplementation with 200 and 800 mg/kg feed HDE (HDE200 and HDE800, respectively) resulted in no significant difference in growth in the HFD-fed groups. The triglyceride (TG) levels and free fatty acids were significantly decreased, whereas high-density lipoprotein cholesterol was increased in the HDE800 group (P < .05). The hepatic intracellular TGs were significantly decreased in the HDE-fed groups and lipogenic enzymes (acetyl CoA carboxylase, fatty acid synthase, stearoyl CoA desaturase, and diacylglycerol transferase) in the liver were significantly downregulated by HDE supplementation (P < .05). The diminished serum antioxidant enzyme activities in the HFD group were effectively restored by HDE supplementation, which also contributed to the attenuation of hyperlipidemia. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.title | Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Gwang-woong | - |
dc.identifier.doi | 10.1089/jmf.2018.4224 | - |
dc.identifier.scopusid | 2-s2.0-85060460398 | - |
dc.identifier.wosid | 000451529100001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MEDICINAL FOOD, v.22, no.1, pp.74 - 80 | - |
dc.relation.isPartOf | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.title | JOURNAL OF MEDICINAL FOOD | - |
dc.citation.volume | 22 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 74 | - |
dc.citation.endPage | 80 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002434101 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | LIPOPROTEIN CHOLESTEROL | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | LIVER-INJURY | - |
dc.subject.keywordPlus | DYSLIPIDEMIA | - |
dc.subject.keywordPlus | LIPOGENESIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | DIHYDROMYRICETIN | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | TRIGLYCERIDES | - |
dc.subject.keywordAuthor | antioxidant enzymes | - |
dc.subject.keywordAuthor | hepatic lipid accumulation | - |
dc.subject.keywordAuthor | Hovenia dulcis Thunb. extract | - |
dc.subject.keywordAuthor | hyperlipidemia | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/jmf.2018.4224 | - |
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