노인에서 인지 저하가 두통 발생 빈도에 미치는 영향

Abstract

Background: Relationship between cognitive impairment and headache is not well published. There are some researches that headache affects cognitive impairment or dementia but rare researches on the opposite. In this study, we sought to find out how cognitive impairment affects to headache. Methods: We enrolled over 65 year-old patients who have a chronic headache and take pills above 8 days a month for relieving headache. Patients took examination of Korean Mini-Mental State Examination (K-MMSE) and Clinical Dementia Rating (CDR) on the day of visiting and follow-up examinations after 2 years later. Outcome is the improvement of headaches caused by cognitive deterioration. Cognitive deterioration is defined as increasing 1 or more on follow-up CDR test and headache improvement is defined as decreasing of more than half on taking analgesics. Result: Total 58 patients were enrolled. 15 patients (25.9%) showed cognitive deterioration with significant decreasing of K-MMSE. The deterioration group was older (76.3±5.2), women dominated (86.7%) and poor initial CDR (0.57±0.42) but has no statistical significant of p=0.08, p≥0.999, p=0.1, respectively. In deterioration group, 8 patients (53.5%) showed decreasing of frequency of taking analgesic with statistical significant (p<0.01). Conclusion: In the elderly patients with chronic headache, the day of analgesic use decreased significantly if cognitive function was deteriorated.