Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial
DC Field | Value | Language |
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dc.contributor.author | Park, Yongsoon | - |
dc.contributor.author | Choi, Jeong-Eun | - |
dc.contributor.author | Hwang, Hwan-Sik | - |
dc.date.accessioned | 2022-07-10T23:02:10Z | - |
dc.date.available | 2022-07-10T23:02:10Z | - |
dc.date.created | 2021-05-12 | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/149059 | - |
dc.description.abstract | Background: Age-related loss of muscle mass and function is a major component of frailty. Nutrition supplementation with exercise is an effective strategy to decrease frailty by preventing sarcopenia, but the effect of protein alone is controversial. Objective: The present study was performed to investigate a dose-dependent effect of protein supplementation on muscle mass and frailty in prefrail or frail malnourished elderly people. Design: A 12-wk double-blind randomized controlled trial was conducted in elderly subjects aged 70-85 y with >= 1 of the Cardiovascular Health Study frailty criteria and a Mini Nutritional Assessment score <= 23.5 (n = 120). Participants were randomly assigned to 1 of 3 groups: 0.8, 1.2, or 1.5 g protein . kg(-1) . d(-1), with concealed allocation and intention-to-treat analysis. Primary outcomes were appendicular skeletal muscle mass (ASM) and skeletal muscle mass index (SMI) measured by dual-energy X-ray absorptiometry. Results: After the 12-wk intervention, the 1.5-g protein . kg(-1) . d(-1) group had higher ASM (mean +/- SD: 0.52 +/- 0.64 compared with 0.08 +/- 0.68 kg, P = 0.036) and SMI (ASM/weight: 0.87% +/- 0.69% compared with 0.15% +/- 0.89%, P = 0.039; ASM/BMI: 0.02 +/- 0.03 compared with 0.00 +/- 0.04, P = 0.033; ASM: fat ratio: 0.04 +/- 0.11 compared with -0.02 +/- 0.10, P = 0.025) than the 0.8-g protein . kg(-1) . d(-1) group. In addition, gait speed was improved in the 1.5-g protein . kg(-1) . d(-1) group compared with the 0.8-g protein . kg(-1) . d(-1) group (0.09 +/- 0.07 compared with 0.04 +/- 0.07 m/s, P = 0.039). There were no significant differences between the 1.2- and 0.8-g protein . kg(-1) . d(-1) groups in muscle mass and physical performance. No harmful adverse effects were observed. Conclusions: The present study indicates that protein intake of 1.5 g . kg(-1) . d(-1) has the most beneficial effects in regard to preventing sarcopenia and frailty compared with protein intakes of 0.8 and 1.2 g . kg(-1) . d(-1) in prefrail or frail elderly subjects at risk of malnutrition. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.title | Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongsoon | - |
dc.contributor.affiliatedAuthor | Hwang, Hwan-Sik | - |
dc.identifier.doi | 10.1093/ajcn/nqy214 | - |
dc.identifier.scopusid | 2-s2.0-85057212593 | - |
dc.identifier.wosid | 000456094800015 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF CLINICAL NUTRITION, v.108, no.5, pp.1026 - 1033 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.title | AMERICAN JOURNAL OF CLINICAL NUTRITION | - |
dc.citation.volume | 108 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1026 | - |
dc.citation.endPage | 1033 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | OLDER-ADULTS | - |
dc.subject.keywordPlus | DIETARY-PROTEIN | - |
dc.subject.keywordPlus | HEALTHY OLDER | - |
dc.subject.keywordAuthor | protein supplementation | - |
dc.subject.keywordAuthor | muscle mass | - |
dc.subject.keywordAuthor | frailty | - |
dc.subject.keywordAuthor | elderly | - |
dc.subject.keywordAuthor | clinical trial | - |
dc.subject.keywordAuthor | malnutrition | - |
dc.identifier.url | https://academic.oup.com/ajcn/article/108/5/1026/5201551 | - |
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